Is there any role of Toxoplasma gondii in the etiology of obsessive-compulsive disorder?

Psychiatry Research
Ozlem MimanSuheyla Unal

Abstract

Obsessive-compulsive disorder (OCD) is a common psychiatric illness. Although the aetiology of OCD is still unknown, the family-genetic data show that familial forms of OCD may be associated with a specific genetic susceptibility. Recent investigations have associated development of OCD with infectious illness. Toxoplasmic encephalitis (TE) is a common presentation of Toxoplasma gondii infection of the central nervous system (CNS). The most commonly affected CNS region in TE is the cerebral hemisphere, followed by the basal ganglia, cerebellum and brain stem. The basal ganglia has been implicated in the development of OCD. Therefore, in this study, it was aimed to investigate a possible association between Toxoplasma infection and OCD. We selected 42 patients with OCD and 100 healthy volunteers, and investigated the sero-positivity rate for anti-Toxoplasma IgG antibodies by Enzyme Linked Immunosorbent Assay (ELISA). The sero-positivity rate for anti-T. gondii IgG antibodies among OCD patients (47.62%) was found to be significantly higher than the rate in healthy volunteers (19%). This is the first report to examine a potential association between Toxoplasma infection and OCD. The main finding of the present study is an increase...Continue Reading

References

Jun 9, 1998·Annals of the New York Academy of Sciences·M Asberg
Oct 13, 2001·European Child & Adolescent Psychiatry·A BrynskaT Wolanczyk
Feb 11, 2005·Eukaryotic Cell·Stacy L PflugerKristin M Hager
Mar 25, 2005·Physiological Reviews·I Caroline McMillen, Jeffrey S Robinson
Feb 27, 2007·Schizophrenia Bulletin·Vern B Carruthers, Yasuhiro Suzuki
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Felipe Filardi da RochaAntonio Lucio Teixeira
Feb 7, 2009·The Journal of Neuropsychiatry and Clinical Neurosciences·Edward D HueyJordan Grafman
Feb 13, 2009·Neuroimmunomodulation·S A HenriquezC W Roberts

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Citations

Nov 5, 2013·International Journal for Parasitology·Isabelle Coppens
Jul 12, 2012·Folia Parasitologica·Wojciech GuenterAlina Borkowska
Mar 5, 2013·The Psychiatric Quarterly·Jack Castro, Stephen Billick
Oct 26, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Amir AbdoliFatemeh Ghaffarifar
Mar 31, 2010·Neuroscience Letters·Ozlem MimanZafer Cetinkaya
Dec 3, 2015·Depression and Anxiety·Jasmine TurnaMichael Van Ameringen
Aug 16, 2014·Brain, Behavior, and Immunity·Adam A MarkovitzAllison E Aiello
Apr 18, 2015·BMC Infectious Diseases·Cosme Alvarado-EsquivelIsabel Beristain-García
Feb 26, 2013·Trends in Parasitology·Jaroslav Flegr
Jun 15, 2011·Psychiatry Research·William TaboasSteven Taylor
Aug 10, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M Nourollahpour ShiadehS J Seyyedtabaei
Jan 15, 2014·American Journal of Alzheimer's Disease and Other Dementias·Joseph Prandota
Nov 2, 2018·Nordic Journal of Psychiatry·Özlem MimanMetin Atambay
Apr 11, 2019·PLoS Neglected Tropical Diseases·Tooran Nayeri ChegeniAhmad Daryani
Apr 30, 2019·Transactions of the Royal Society of Tropical Medicine and Hygiene·Maryam SadeghiAli Rostami
Jun 1, 2012·Evolutionary Applications·Frédéric ThomasMichel Raymond
Dec 4, 2012·Expert Review of Anti-infective Therapy·Laura VanagasSergio O Angel
Jul 23, 2019·Journal of Addictive Diseases·Ekramy ElmorsyMohammed Shoaib
Jun 18, 2020·Brain Sciences·Gloria Ortiz-GuerreroMauricio O Nava-Mesa
Nov 24, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Ajish G Mangot
Feb 22, 2017·Journal of Food Protection·Declan J Bolton, Lucy J Robertson
Aug 2, 2019·Current Psychiatry Reports·Mona GerentesNora Hamdani
Mar 7, 2020·Frontiers in Psychiatry·Jaroslav Flegr, Jiří Horáček
Aug 12, 2018·Brain Sciences·Hugues LamotheLuc Mallet
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
Dec 20, 2016·European Psychiatry : the Journal of the Association of European Psychiatrists·J Flegr, J Horáček
Nov 4, 2020·Annual Review of Animal Biosciences·Stefanie K Johnson, Pieter T J Johnson

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