PMID: 9557162Apr 29, 1998Paper

Is there IgA from gut mucosal origin in the serum of children with Henoch-Schönlein purpura?

Clinical Immunology and Immunopathology
P MojaC Genin

Abstract

Thirty-two children with Henoch-Schönlein purpura with or without renal symptoms were studied to characterize the IgA hyperglobulinemia observed in the serum of most patients. It was shown that only the IgA1 subclass concentration was increased. Secretory IgA and IgA to gliadin levels were frequently increased in serum, with a good correlation between them. Circulating IgA immune complexes were detected often and contained high activity to gliadin. In contrast, IgA activity to tetanus toxoid did not change. We failed to show any differences in renal involvement. These data suggest that elevation of serum IgA in Henoch-Schönlein purpura is due in part to a disturbance of the gut mucosal immune system, and the presence of circulating IgA immune complexes with dietary antigens can be postulated but cannot explain the occurrence of urinary symptoms.

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Citations

Dec 3, 1999·The British Journal of Dermatology·C A EganJ J Zone
Jul 5, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·G Rostoker
Jul 12, 2013·Fukushima Journal of Medical Science·Yukihiko KawasakiMitsuaki Hosoya
Mar 21, 2008·Digestive Diseases and Sciences·Ellen C Ebert
Jun 23, 2011·Clinical and Experimental Nephrology·Yukihiko Kawasaki
Sep 10, 2011·Pediatrics International : Official Journal of the Japan Pediatric Society·Yukihiko Kawasaki
Aug 3, 2000·Seminars in Arthritis and Rheumatism·E PertuisetA M Chesneau
May 28, 2020·Nature Reviews. Rheumatology·Magali Noval Rivas, Moshe Arditi
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·A RaiS Adler
Oct 18, 2005·La Presse médicale·P GuilpainL Mouthon

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