Is there relationship between epicardial fat and cardiovascular parameters in incident kidney transplant patients? A post-hoc analysis

PloS One
Daniel Constantino YazbekMaria Eugênia F Canziani

Abstract

Epicardial fat (EF) has been related to increased cardiovascular risk in chronic kidney disease patients. Kidney transplantation is associated with weight gain, especially within the first 12 months. Recently an association between EF and left ventricular mass (LVM) has been suggested in kidney transplant (KTX) recipients. Evaluate the EF in KTX recipients and its association with cardiovascular parameters in a 12-month follow-up study. EF volume was determined using thoracic computed tomography. The EF progressor group (EF gain) was defined by any increment in EF after 12 months. LVM and LVM index were calculated by echocardiography. Ninety-eight incident KTX patients [57% men, 41.2 ± 10.1 years, mean dialysis time prior to transplant of 24 (11-60) months] were analyzed. At baseline and after 12 months, EF was 318.6 (275.2-392.6) ml and 329.5 (271.7-384.8) ml, respectively (p = 0.03). When compared to patients who EF decreased (n = 33), those with EF gain (n = 65) had a greater increase of body mass index, abdominal circumference and blood glucose. These patients also had a lower reduction of LVM index. However in the multivariate analysis, there was no difference in LVM index change between groups (interaction p = 0.565), eve...Continue Reading

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Citations

Mar 6, 2019·Journal of Clinical Medicine·Narothama Reddy AeddulaSamata Pathireddy
May 8, 2021·Current Hypertension Reports·Christos ChatzikyrkouMario Schiffer

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