Is there significant improvement in neonatal outcome after treating pPROM mothers with amnio-infusion?

Biology of the Neonate
Maria Pia De CarolisAlessandro Caruso

Abstract

The aim of this study was to determine the effects of amnio-infusion treatment on fetal and neonatal mortality and neonatal pulmonary development in women with singleton pregnancies and premature rupture of the membranes occurring at a gestational age of <26 weeks and who had severe oligohydramnios. The treated group of 45 consenting women received serial amnio-infusion and was compared with the control group of 44 women who underwent waiting treatment. Our study confirmed a higher number of live births in the treated group, especially in cases with a gestational age at rupture (GAR) of <20 weeks. Furthermore, even if GAR is an important factor for predicting pulmonary hypoplasia, amnio-infusion treatment reduces the probability of pulmonary hypoplasia. In fact, over 20 weeks, amnio-infusion treatment significantly reduces the risk of pulmonary hypoplasia even if normal lung development cannot be guaranteed.

Citations

Mar 20, 2010·Surgical Endoscopy·Thomas Kohl
Jan 6, 2007·European Journal of Pediatrics·Markus J Kemper, Dirk E Mueller-Wiefel
Nov 23, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·D RobertsZ Alfirevic
Jun 18, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wiebke Aulbert, Markus J Kemper
Jun 4, 2014·Journal of Pediatric Surgery·Julie Di BernardoShaun M Kunisaki
Oct 28, 2019·The Journal of Obstetrics and Gynaecology Research·Takeshi OnoMasatoshi Yokoyama
Aug 13, 2005·Fetal and Pediatric Pathology·Maria M Rodriguez

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