Is thymectomy in non-thymomatous myasthenia gravis of any benefit?

Interactive Cardiovascular and Thoracic Surgery
Andres DiazJoel Dunning

Abstract

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was if thymectomy in non-thymomatous myasthenia gravis was of any benefit? Overall, 137 papers were found using the reported search, of which 16 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. The outcome variables were similar in all of the papers, including complete stable remission (CSR), pharmacological remission, age at presentation, gender, duration of symptoms, preoperative classification (Oosterhius, Osserman or myasthenia gravis Foundation of America (MGFA)), thymic pathology, preoperative medications (steroids, immunosuppressants), mortality and morbidity. We conclude that evidence-based reviews have shown that relative rates of thymectomy patients compared with non-thymectomy patients attaining outcome indicate that the former group of patients is more likely to achieve medication-free remission, become asymptomatic and clinically improve (54%, P < 0.01), particularly patients with severe and generalized symptoms (P = 0.007). Patients with gen...Continue Reading

References

Oct 1, 1990·Journal of Neurology·R MantegazzaP Tonali
Feb 1, 1994·The Annals of Thoracic Surgery·W H FristH W Bender
Sep 1, 1996·The Annals of Thoracic Surgery·A MasaokaY Monden
Jul 1, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F VenutaG F Coloni
Jul 24, 2001·The Annals of Thoracic Surgery·J M BuddeJ I Miller
Jan 12, 2002·Respiration; International Review of Thoracic Diseases·M de PerrotA Spiliopoulos
Apr 5, 2002·Current Treatment Options in Neurology·Gary S. Gronseth, Richard J. Barohn
Aug 21, 2003·Surgery Today·Turkan TanselUfuk Alpagut
Dec 19, 2003·Asian Cardiovascular & Thoracic Annals·Yasser El-MedanyMahmoud Ashour
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Joel DunningKevin Mackway-Jones
Oct 2, 2007·Clinical Neurology and Neurosurgery·Naoki KawaguchiTakamichi Hattori
Jun 24, 2008·Annals of the New York Academy of Sciences·Joshua R Sonett, Alfred Jaretzki
Apr 3, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Eugenio PompeoTommaso Claudio Mineo
Jul 21, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Mong-Wei LinYung-Chie Lee

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Citations

Dec 18, 2015·Expert Review of Clinical Immunology·Amelia EvoliEmanuela Bartoccioni
Oct 16, 2015·Cirugía española·Francisco J Vázquez-RoqueDeysi Rivero-Valerón
Jan 23, 2016·Interactive Cardiovascular and Thoracic Surgery·Friedhelm BeyersdorfMatthias Siepe
Jan 15, 2016·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Friedhelm BeyersdorfMatthias Siepe
Jul 29, 2015·Biochemical Pharmacology·Jie Luo, Jon Lindstrom
Jun 28, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gaetano Rocco
Dec 30, 2014·Orphanet Journal of Rare Diseases·Carolina BarnettVera Bril
Dec 9, 2014·Biochimica Et Biophysica Acta·James C Ha, David P Richman
Apr 27, 2016·Acta Clinica Belgica·Dorina EsendagliSalih Emri
Jun 9, 2016·Clinical Reviews in Allergy & Immunology·Frédérique TruffaultSonia Berrih-Aknin
Nov 8, 2016·The International Journal of Neuroscience·Jing YangChengyan Li
Mar 17, 2017·Pathology Oncology Research : POR·Ping ChenGang Zhao
Mar 29, 2019·Expert Review of Neurotherapeutics·Amelia Evoli, Elisa Meacci
Feb 8, 2019·Pediatric Surgery International·Aimee G KimThane A Blinman
Jan 31, 2019·Frontiers in Neurology·Huan LuoJing Cao
Jun 18, 2017·Frontiers in Immunology·Ralf J LudwigFalk Nimmerjahn
Jun 11, 2017·Journal of Neuroinflammation·K M DanikowskiB S Prabhakar
Apr 28, 2021·Neurology India·A S ShreedharaC Sarada

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