PMID: 6110823Mar 14, 1981Paper

Is thyrotropin releasing hormone an endogenous ergotropic substance in the brain?

Lancet
G Metcalf, P W Dettmar

Abstract

The neuropharmacological profile for thyrotropin releasing hormone (TRH) has been compared with various other types of central nervous system stimulants, and the results of the comparison, considered together with the results obtained by other workers, suggest that TRH may function as an endogenous ergotropic substance. Its ergotropic properties suggest that TRH analogues with better biological stability than the parent compound may be useful agents for treating some psychiatric disorders; for hastening the recovery of consciousness and respiration after anaesthesia; for treating narcotic overdosage or dependence, narcolepsy, minimal brain damage, and various neuromuscular disorders; and for aiding the diagnosis of "brain death".

References

Jan 1, 1979·Progress in Neurobiology·G G Yarbrough
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Citations

Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S A StwertkaA G Verderese
Jan 1, 1983·Pharmacology & Therapeutics·W G Clark, J M Lipton
Mar 30, 1996·Lancet·J N Blau
Jan 7, 1998·Bioorganic & Medicinal Chemistry·A A MazurovT A Voronina
Oct 29, 1981·The New England Journal of Medicine·A J Prange, R D Utiger
Jan 21, 1982·The New England Journal of Medicine·I M Jackson
Mar 1, 1991·Acta Physiologica Scandinavica·M NinkJ Beyer
Jan 11, 1992·Annals of the New York Academy of Sciences·A J Prange
Oct 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·R J GuiloffS L Lightman
Dec 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·R J GuiloffS L Lightman
Aug 1, 1982·General and Comparative Endocrinology·E C GriffithsA I Smith
Jan 1, 1982·Annals of the New York Academy of Sciences·A J Prange, C B Nemeroff
Oct 26, 1999·Endocrine Reviews·E A Nillni, K A Sevarino
Apr 1, 1987·Reviews in the Neurosciences·R J Guiloff
Apr 16, 1999·Psychosomatic Medicine·A J Prange
Jan 1, 1982·Acta Medica Scandinavica·A Nygren, S Röjdmark
Jun 1, 1983·The Journal of Pharmacy and Pharmacology·P W DetimarB A Morgan

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