Is Tibiofemoral or Patellofemoral Alignment or Trochlear Morphology Associated With Patellofemoral Osteoarthritis? A Systematic Review

Arthritis Care & Research
Erin M MacriKay M Crossley

Abstract

We conducted a systematic review to evaluate the associations of knee alignment or trochlear morphology (measured on imaging) with presence, severity, onset, and/or progression of patellofemoral osteoarthritis (PFOA). We prospectively registered our protocol with PROSPERO (International prospective register of systematic reviews) and followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines to report this review. We searched 10 electronic databases, screened citing articles, and reviewed reference lists. We extracted data and evaluated methodologic quality. Due to study design heterogeneity, we used a best-evidence synthesis to summarize the evidence. We included 16 publications (2,892 participants, 66% women) after removing 4 papers that did not meet our threshold for methodologic quality. There were 11 cross-sectional and 5 longitudinal papers. The target population was knee OA in 11 studies, PFOA in 2 studies, and other knee conditions in 3 studies. Alignment or morphology was measured using radiographs in 8 studies, magnetic resonance imaging in 7 studies, and computed tomography in 2 papers. Limitations include substantial heterogeneity in samples and methods, short followup times ...Continue Reading

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Citations

Jan 20, 2018·Rheumatology·Priathashini KrishnasamySarah R Robbins
Jan 29, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Erin M MacriKarim M Khan
Nov 6, 2018·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Sara Weintraub, Ronnie Sebro
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May 13, 2020·Current Reviews in Musculoskeletal Medicine·Mitchell G A WheatleyAllison L Clouthier
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May 11, 2017·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Erin M MacriKay M Crossley
May 18, 2021·Journal of Clinical Orthopaedics and Trauma·Marcos Vinicius da Silva BoitragoMarcio Oliveira
Aug 24, 2021·BMJ Open Sport & Exercise Medicine·Erin M MacriKarim M Khan

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