Is tissue transglutaminase autoantibody the best for diagnosing celiac disease in children of developing countries?

Journal of Clinical Gastroenterology
Ujjal PoddarKartar Singh

Abstract

To prospectively evaluate the role of tissue transglutaminase (tTG) antibody in detecting celiac disease (CD) in Indian children. Over a period of 3 years, 333 children (<or=14 y of age) with suspected CD were evaluated. CD was diagnosed on the basis of modified ESPGHAN criteria. Antibody to tTG (guinea-pig) was detected by commercial enzyme-linked immunosorbent assay kit. Children with a suspicion of CD but found to have normal villous architecture were taken as controls. Antiendomysial antibody (EMA) and IgA-antigliadin antibody were done in 80 cases and 40 controls. The mean age of 180 children with CD was 6.5+/-3 years with a male to female ratio of 1.7:1. Their presenting complaints were diarrhea in 84% and failure to thrive in 87%. Wasting, stunting, and anemia were seen in 87%, 59%, and 83% of cases, respectively. The best sensitivity and specificity of tTG antibody we have got at a cut-off value of 10 U/mL and were 94% and 97%, respectively, with a positive predictive value of 98% and negative predictive value of 92.4%. The mean tTG antibody titer was 106+/-76 U/mL in cases and 2+/-1.6 U/mL in controls (P<0.001). The concordance of tTG antibody with EMA was 95% in cases and 97.5% in controls. tTG antibody is a highly se...Continue Reading

References

Apr 1, 1992·Journal of Internal Medicine·E LindhB Lavö
Aug 1, 1991·Archives of Disease in Childhood·A Bürgin-WolffC Reymond-Berthet
Sep 1, 1990·Archives of Disease in Childhood·J A Walker-Smith
Nov 19, 1966·British Medical Journal·B N WaliaS Bhargava
Jun 14, 1997·Lancet·M Mäki, P Collin
Dec 3, 1998·Gastroenterology·W DieterichD Schuppan
Feb 5, 1999·The Journal of Pediatrics·R TronconeL Sacchetti
Nov 5, 1999·Digestive Diseases·P CollinM Mäki
Nov 30, 1999·Journal of Pediatric Gastroenterology and Nutrition·J C VitoriaM D García-Masdevall
May 16, 2000·The American Journal of Gastroenterology·D SblatteroT Not
Oct 11, 2001·Journal of Pediatric Gastroenterology and Nutrition·J C VitoriaA Ayesta
Dec 26, 2001·Journal of Pediatric Gastroenterology and Nutrition·Maria Grazia ClementeStefano De Virgiliis
Oct 24, 2002·Journal of Pediatric Gastroenterology and Nutrition·Ujjal PoddarKartar Singh
Feb 19, 2003·Journal of Clinical Gastroenterology·Antonio TursiGian Marco Giorgetti
Apr 30, 2003·Journal of Clinical Pathology·E TonuttiUNKNOWN French-Italian Laboratory Study Group on Coeliac Disease
Jun 20, 2003·The New England Journal of Medicine·Markku MäkiMikael Knip
Jan 22, 2004·Journal of Pediatric Gastroenterology and Nutrition·Jonas F LudvigssonJohnny Ludvigsson
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edwin LiuEdward J Hoffenberg
Aug 2, 2005·Journal of Pediatric Gastroenterology and Nutrition·Shinjini BhatnagarMaharaj K Bhan

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Citations

May 30, 2013·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Ujjal Poddar
Apr 1, 2009·Digestive Diseases and Sciences·Amit Kumar DuttaBalekuduru Avinash
Dec 18, 2015·Indian Journal of Pediatrics·Siba Prosad Paul, Emily Natasha Kirkham
Sep 18, 2009·Annals of the New York Academy of Sciences·Thomas S AlexanderLinda Define
Sep 23, 2014·Critical Reviews in Clinical Laboratory Sciences·Vilte E BarakauskasMathew P Estey

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