Is topical antimycotic treatment useful as adjuvant therapy for flexural atopic dermatitis: randomized, double-blind, controlled trial using one side of the elbow or knee as a control

International Journal of Dermatology
Alson W K WongBenny Zee

Abstract

Certain factors are known to cause exacerbation of atopic dermatitis (AD), e.g. soap, detergent, dry skin, staphylococcal colonization, and herpes infection. Other factors are suspected, but not yet proven, e.g. yeasts belonging to the Malassezia genus. It is known that antimycotics may be beneficial in a small subset of adult patients with dermatitis affecting the head and neck region; however, it is not known whether AD patients, many of whom also have head and neck involvement, may also find antimycotics useful. A previous study has demonstrated no treatment difference in adult AD patients; however, the measurement method was criticized and 1% hydrocortisone cream may have too weak an effect in adult patients. Therefore, we designed this randomized, double-blind, controlled trial to examine this question. Younger AD patients were recruited and different methods of measuring outcomes were used. To evaluate the usefulness of topical antimycotic treatment as adjuvant therapy for flexural AD. Methods This was a randomized, double-blind, controlled trial in AD patients using one side of the elbow or knee as a control. There were three independent outcomes: (i) to compare the ability to relieve symptoms; (ii) to compare the abilit...Continue Reading

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Citations

May 22, 2013·Journal of Dermatological Science·Carren S HauShinichi Watanabe
Mar 9, 2013·The Journal of Dermatological Treatment·Nasrin SakiSoheila Alyaseen
May 10, 2012·Expert Opinion on Pharmacotherapy·Gérald E PiérardClaudine Piérard-Franchimont
Apr 15, 2016·The Journal of Dermatology·Hidehisa SaekiUNKNOWN Committee for Clinical Practice Guidelines for the Management of Atopic Dermatitis of Japanese Dermatological Association
Jun 4, 2013·The Journal of Allergy and Clinical Immunology·Takaaki HiragunMichihiro Hide
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May 14, 2014·Dermatitis : Contact, Atopic, Occupational, Drug·Petra BrodskáPeter Schmid-Grendelmeier
Oct 11, 2019·The Journal of Dermatology·Norito KatohKiwako Yamamoto-Hanada
Jun 10, 2020·Clinical and Translational Allergy·Sabine AltrichterMarcus Maurer
Aug 23, 2016·The British Journal of Dermatology·H NankervisH C Williams

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.