Is treatment-resistant depression a useful concept?

Evidence-based Mental Health
Gin S Malhi, Yulisha Byrow

Abstract

The term treatment-resistant depression (TRD) is widely used in the context of managing mood disorders, but defining it, both conceptually and in practice, has proven difficult. Most definitions have focused on pharmacotherapy but even these have struggled to capture the complexity of varying response and duration of treatment. Both clinically and for research studies a meaningful definition of TRD is necessary because it may lead to the development of 'therapy-defined depressive subtypes' and the discovery of novel antidepressants. This brief perspective critically reviews the concept of treatment resistance and how it can be more clearly defined so as to achieve a better understanding of depression and facilitate clinical treatment trials.

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Citations

Oct 6, 2016·BJPsych Open·Gin S MalhiMauricio Tohen
Apr 8, 2016·Evidence-based Mental Health·Jaclyn SchwartzDan V Iosifescu
Mar 27, 2016·L'Encéphale·G S Malhi
Feb 26, 2016·The Australian and New Zealand Journal of Psychiatry·Gin S MalhiGreg Murray
Jun 10, 2017·Expert Review of Neurotherapeutics·Gopalkumar RakeshPrakash S Masand
Nov 18, 2018·The International Journal of Neuropsychopharmacology·Bashkim KadriuCarlos A Zarate
Sep 10, 2019·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Koen Demyttenaere
Dec 20, 2018·The British Journal of Psychiatry : the Journal of Mental Science·Gin S MalhiLauren Irwin
Jun 24, 2020·European Psychiatry : the Journal of the Association of European Psychiatrists·Clara López-SolàNarcís Cardoner
May 7, 2021·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Gin S MalhiZola Mannie
Jul 31, 2021·World Journal of Psychiatry·Adejoke Yetunde Onaolapo, Olakunle James Onaolapo

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