PMID: 9534911Apr 16, 1998Paper

Is tyrosine kinase activation involved in basophil histamine release in asthma due to western red cedar?

Allergy
A J FrewM Chan-Yeung

Abstract

Occupational asthma due to western red cedar is associated with histamine release from basophils and mast cells on exposure to plicatic acid (PA), but the mechanisms underlying this response remain unclear. Specific kinase inhibitors were used to study the role of tyrosine and serine/threonine kinases in PA-induced histamine release from human basophils. Pretreatment with the tyrosine kinase inhibitor methyl 2,5-dihydroxy-cinnamate (MDHC) attenuated histamine release from basophils triggered by anti-IgE (29.8% inhibition; n = 15; P < 0.01) or grass pollen (48% inhibition; n = 6; P < 0.01). Inhibition was concentration-dependent and could be reversed by washing the cells in buffer, while the inactive stereoisomer of MDHC did not affect histamine release. In contrast, the protein kinase C inhibitor staurosporine did not affect histamine release by either anti-IgE or grass pollen. Pretreatment with MDHC partially inhibited PA-induced histamine release from basophils of 6/9 patients with red cedar asthma (25.4% vs 33.8%; P = NS). Staurosporine gave a similar level of inhibition of PA-induced histamine release (25.3% vs 33.8%; P = NS). Thus, signal transduction of the human basophil Fc epsilon RI appears to depend upon tyrosine kina...Continue Reading

References

Jun 1, 1992·Immunology Today·M Benhamou, R P Siraganian
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M BenhamouR P Siraganian
Sep 1, 1990·Cellular and Molecular Neurobiology·D A Carter, D Murphy
Nov 1, 1989·The Journal of Allergy and Clinical Immunology·M Chan-YeungS Lam
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·A M Scharenberg, J P Kinet
Sep 1, 1993·The Journal of Allergy and Clinical Immunology·A FrewM Chan-Yeung

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Citations

Aug 10, 2000·Environmental Health Perspectives·L J Lombardo, J R Balmes

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