Is ultrasound a better target than clinical disease activity scores in rheumatoid arthritis with fibromyalgia? A case-control study

PloS One
Rafael Mendonça da Silva ChakrRicardo Machado Xavier

Abstract

Our goal is to study the correlations among gray-scale seven-joint ultrasound score (GS-US7), power Doppler seven-joint ultrasound score (PD-US7), disease activity score-28 joints (DAS28), simplified disease activity index (SDAI) and clinical disease activity index (CDAI) in patients with and without fibromyalgia (FM). A matched case-control study included all patients consecutively seen in the Rheumatoid Arthritis (RA) Clinic. Participants were allocated into one of two groups: RA with FM and RA without FM. Ultrasound (US) and clinical scoring were blinded for the presence of FM. Medians and proportions were compared by Mann-Whitney's test and McNemar's test, respectively. Spearman's rank correlation coefficients (rs) were calculated among clinical and US scores and differences were tested by r-to-z transformation test. Seventy-two women were included, out of 247 RA patients, mostly white, with median (IQR) age of 57.5 (49.3-66.8) years, with RA symptoms for 13.0 (6.0-19.0) years and FM symptoms for 6.0 (2.0-15.0) years. Disease-modifying antirheumatic drugs, non-steroidal anti-inflammatory drugs and prednisone use was comparable between groups. Objective activity parameters were not different between groups. RA patients with ...Continue Reading

References

Apr 11, 2003·Arthritis and Rheumatism·Marcin SzkudlarekMikkel Østergaard
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Jun 15, 2011·Best Practice & Research. Clinical Rheumatology·Loreto CarmonaLyn March
Dec 21, 2012·Annals of the Rheumatic Diseases·Sarah Ohrndorf, Marina Backhaus
Mar 23, 2013·Annals of the Rheumatic Diseases·Alexandra N ColebatchPhilip G Conaghan
May 24, 2013·Clinical Rheumatology·Rafael Mendonça da Silva ChakrJoão Carlos Tavares Brenol

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Citations

Jan 4, 2017·Revista brasileira de reumatologia·Rafael Mendonça da Silva ChakrRicardo M Xavier
Dec 21, 2018·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·William S Wilke
Jan 19, 2019·Advances in Rheumatology·Aline Defaveri do PradoJoão Eurico Fonseca
Aug 5, 2019·Rheumatology International·Nada Mahmoud ShresherMohsen Hassan Elshahaly
Nov 22, 2016·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Aline Defaveri do PradoHenrique Luiz Staub
Jan 21, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Rafael Mendonça da Silva ChakrClaiton Viegas Brenol

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Methods Mentioned

BETA
ESR

Software Mentioned

SPSS
WinPepi

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