Is Use of Topical Vancomycin in Pediatric Spine Surgeries a Safe Option in the Prevention of Surgical Site Infections? A Meta-analysis and Systematic Review of the Literature.

Global Spine Journal
Muthu Sathish, Chellamuthu Girinivasan

Abstract

Systematic review and meta-analysis. To systematically review the available articles on topical vancomycin powder (TVP) use in pediatric spine surgeries exploring the usefulness and safety of such practice. We conducted an independent and duplicate electronic database search in PubMed, EMBASE, and Cochrane Library till March 2020 to identify all relevant literature on the use of TVP for pediatric spine surgeries. Surgical site infection (SSI) rate, specific reported complications, reoperation rate, microbial flora pattern in reported SSIs, and safety profile were the outcomes analyzed. Analysis was performed with the R platform using OpenMeta[Analyst] software. No prospective studies were available to evaluate the use of TVP in pediatric spine surgeries for the prevention of SSIs. Neither standardized protocol, nor drug dosage, nor safety profile was established for pediatric use. Three retrospective cohort studies including 824 patients (TVP/control: 400/424) were included in the meta-analysis. There was low-quality evidence suggesting no significant difference between the 2 groups in SSI rate (RR = 0.474; 95% CI = [0.106,2.112]; P = .327) with significant heterogeneity (I2 = 70.14; P = .035). The TVP group showed a significan...Continue Reading

References

Apr 6, 1999·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·F GeigerC Carstens
Jun 18, 2003·Spine·Maurits van TulderUNKNOWN Editorial Board of the Cochrane Collaboration Back Review Group
Dec 31, 2010·Spine·Justin S SmithUNKNOWN Scoliosis Research Society Morbidity and Mortality Committee
Jun 14, 2013·Spine·Itai GansKeith D Baldwin
Jun 19, 2013·Journal of Pediatric Orthopedics·Michael P GlotzbeckerUNKNOWN POSNA committee on the Quality, Safety, Value Initiative (QSVI)
Jul 9, 2013·Journal of Neurosurgery. Spine·Ramamani MariappanAnuj Bhatia
Nov 5, 2013·International Journal of Antimicrobial Agents·Tian YuCatherine M T Sherwin
Jan 1, 2014·The Spine Journal : Official Journal of the North American Spine Society·Hsiu-Yin ChiangMarin L Schweizer
May 20, 2014·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Nathan EvaniewMichelle Ghert
Jun 28, 2014·Journal of Neurosurgery. Pediatrics·Sheila L RyanUNKNOWN Texas Children's Hospital Spine Study Group
Apr 24, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Claudia EderMichael Ogon
Oct 2, 2015·Neurosurgical Focus·George M GhobrialJames S Harrop
Aug 3, 2017·International Journal of Spine Surgery·Stacey ChuAlan B C Dang
Dec 22, 2017·Journal of Children's Orthopaedics·C J DeFrancescoUNKNOWN Children’s Spine Study Group
Feb 6, 2018·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yasunori NagahamaJeremy D W Greenlee
Mar 21, 2018·The Journal of Bone and Joint Surgery. American Volume·George H ThompsonR Justin Mistovich
Apr 6, 2018·Foot & Ankle International·Jason T BariteauNick J Willett
Jun 30, 2018·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·John G D CannonGerald A Grant
Jan 21, 2019·The Spine Journal : Official Journal of the North American Spine Society·Abhiram GandeYu-Po Lee
Jan 22, 2019·Orthopedic Reviews·Benjamin ClippingerJohn Handal

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Citations

May 11, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Susan S XieKimberly A Risma

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Software Mentioned

OpenMeta [ Analyst
R
PRISMA

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