Is vascular stiffness a target for therapy?

Cardiovascular Drugs and Therapy
D Duprez

Abstract

Early cardiovascular disease starts in the endothelium leading to functional changes in the vasculature. These changes can be depicted by assessment of arterial stiffness or elasticity. There are several techniques to assess arterial stiffness. Increased arterial stiffness or decreased arterial elasticity has been associated with cardiovascular risk factors. There is now evidence that small artery elasticity is a strong predictor for arterial hypertension. Moreover arterial elasticity provides extra prognostic information beyond arterial blood pressure measurement. Arterial stiffness attenuation may reflect the true reduction of arterial wall damage. ACE-inhibitors, angiotensin II receptor blockers, aldosterone antagonists and calcium antagonists have favorable effects in improving arterial elasticity, while beta-blockers have an inverse effect. Diuretics have not been evaluated. Lipid lowering therapy, some antidiabetic therapy have shown to reduce arterial stiffness. Inflammatory and infectious diseases have been associated with vascular inflammation and consequently increase in arterial stiffness. The effect of anti-inflammatory agents and antiretroviral therapy on arterial stiffness is under investigation. Measurement of ar...Continue Reading

References

Aug 1, 1992·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·S M Finkelstein, J N Cohn
May 11, 1999·Circulation·J BlacherG M London
Jul 27, 2001·Current Hypertension Reports·N WinerJ R Sowers
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·S MeaumeM E Safar
Dec 4, 2002·American Journal of Hypertension·Lawrence M Resnick, Melvin H Lester
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Azra Mahmud, John Feely
Feb 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Tomoki ShokawaNobuoki Kohno
Feb 8, 2006·Circulation·Francesco U S Mattace-RasoJacqueline C M Witteman
Jul 27, 2006·Progress in Cardiovascular Diseases·Ehud Grossman, Franz H Messerli
Aug 4, 2006·Current Hypertension Reports·Daniel A Duprez, Jay N Cohn
Aug 28, 2007·Journal of the American College of Cardiology·Daniel A DuprezJay N Cohn
Sep 12, 2007·Expert Opinion on Therapeutic Targets·Konstantinos TziomalosDimitri P Mikhailidis
Sep 20, 2007·Current Atherosclerosis Reports·Daniel A Duprez, Jay N Cohn
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity·Ronald B Goldberg
Mar 11, 2008·The Journal of Clinical Hypertension·Gregory P VyssoulisChristodoulos I Stefanadis
Mar 11, 2008·The Journal of Clinical Hypertension·Daniel A Duprez, Jay N Cohn
May 14, 2008·Journal of Hypertension·Peter M NilssonStéphane Laurent
Sep 19, 2008·JAMA : the Journal of the American Medical Association·Jeremiah Stamler, James D Neaton
May 6, 2009·The American Journal of Medicine·Carl J Pepine
May 21, 2009·Journal of Cardiovascular Pharmacology·George Bakris
Sep 5, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jason V BakerKeith Henry
Nov 3, 2009·The Journal of Clinical Hypertension·Thomas D GilesJohn B Kostis
Nov 6, 2009·Future Cardiology·Jay N CohnStanley M Finkelstein
Mar 4, 2010·European Heart Journal·Charalambos VlachopoulosChristodoulos Stefanadis

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Citations

Mar 23, 2011·International Urology and Nephrology·Simona HogasAdrian Covic
Oct 16, 2012·Acta Paediatrica·Marco MeucciScott R Collier
Sep 30, 2014·Pflügers Archiv : European journal of physiology·Antoine TarjusGuillaume Galmiche
Aug 11, 2012·Stroke; a Journal of Cerebral Circulation·Mariëlle M F PoelsM Arfan Ikram
Jul 8, 2018·Current Hypertension Reports·Guanghong JiaJames R Sowers
Feb 18, 2021·BMC Cardiovascular Disorders·Gábor SzalóBledar Daka

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