Is visceral adipose tissue a determinant of von Willebrand factor in overweight and obese premenopausal women?

Metabolism: Clinical and Experimental
Ilse MertensLuc F Van Gaal

Abstract

Visceral obesity has been associated with an increased cardiovascular risk. However, the exact mechanisms are not completely clear. In this study we investigated the relationship between von Willebrand factor (vWF) and visceral adipose tissue (VAT) in a group of 181 overweight and obese premenopausal women visiting the weight management clinic of a university hospital. von Willebrand factor antigen (vWF:Ag), plasminogen activator inhibitor 1 (PAI-1) activity, VAT (computed tomography scan), insulin resistance (homeostasis model assessment of insulin resistance), and other anthropometric and metabolic parameters were measured. Subjects with VAT in the highest quintile had significantly higher levels of vWF:Ag (171+/-60 vs 129+/-40%; P=.001) and PAI-1 (24.7+/-8.5 vs 15.2+/-12.0 AU/mL; P<.001) compared with subjects in the lowest quintile. After correction for fat mass and homeostasis model assessment of insulin resistance the difference was still significant for vWF:Ag (P=.046), but not for PAI-1 (P>.05). Stepwise multiple regression analysis showed VAT and insulin resistance as independent determinants of vWF:Ag, whereas waist circumference, high-density lipoprotein cholesterol, and insulin resistance were independent determinan...Continue Reading

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Citations

Aug 14, 2012·Lipids in Health and Disease·Fareed K N ArthurLawrence Owusu
Apr 20, 2010·Thrombosis Research·Jacob V B HjelmborgAthanase Benetos
Apr 18, 2008·Thrombosis Research·David KarásekDalibor Novotný
Nov 29, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giuseppe LippiMassimo Franchini
Mar 22, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Jean-Pierre DesprésPaul Poirier
Jun 8, 2021·Metabolic Syndrome and Related Disorders·David KarasekLudek Slavik
Jul 3, 2021·Journal of Clinical Medicine·Jan BudzianowskiKatarzyna Korybalska
Dec 8, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Beverly A SchaeferPeter Kouides

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