PMID: 9527965Apr 7, 1998Paper

Is vitamin K1 supplementation necessary in long-term parenteral nutrition?

JPEN. Journal of Parenteral and Enteral Nutrition
C ChambrierP Boulétreau

Abstract

I.v. lipid emulsions contain vitamin K in substantial quantities and in 1989, we therfore stopped supplying vitamin K1 to patients receiving home parenteral nutrition (HPN). Nine patients (group I) receiving HPN before 1989 (10 mg i.v. vitamin K1 supplementation weekly until 1989, which was discontinued thereafter) and six patients with an initial low plasma vitamin K1 concentration (related to their malabsorption) (group II) receiving HPN after 1989 were studied. Prothrombin time (PT), plasma vitamin K1 concentration, and vitamin K1, content in lipid emulsions were measured throughout the period of HPN. All lipid emulsions, except for Eurolip 20% and Clinoleic 20% (Baxter SA, Maurepas, France) contained vitamin K1, with concentration ranges from 179 +/- 39 to 353 +/- 78 ng/L. Group I patients had an initial high plasma vitamin K1 concentration due to the vitamin K1 supplementation. After this supplementation was discontinued, plasma vitamin K1 decreased and remained in normal ranges with a normal PT. Throughout the HPN period after 1989, patients received 255 +/- 104 micrograms of vitamin K1 weekly through lipid emulsions. The PT and plasma vitamin K1 concentrations in group II patients were restored by lipid emulsions, which ...Continue Reading

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Citations

Dec 7, 2011·The American Journal of the Medical Sciences·Lily K CheungDavid J Hyman
Aug 23, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·A L Buchman, A Moukarzel
May 21, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Krishnan Sriram, Vassyl A Lonchyna
Feb 4, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Badr AljarallahJohane P Allard
Jun 5, 2015·JPEN. Journal of Parenteral and Enteral Nutrition·Maria Luisa ForchielliGermana Bersani
Mar 19, 2008·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Donald R Duerksen
Nov 23, 2006·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·M Patricia Fuhrman
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·I E Dupont, Y A Carpentier
Dec 10, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·T O Lipman

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