Is X-linked Recessive Ichthyosis a High Risk for Basal Cell Carcinoma?

Yonago Acta Medica
Keiko WakumotoOsamu Yamamoto

Abstract

We report a case of X-linked recessive ichthyosis with basal cell carcinoma. An 86-year-old man was referred to our department for evaluation of a 1-year history of an ulcer on his left leg. He had suffered from dry skin with scales on his entire body since childhood. Histopathological examination of the lower leg revealed intradermal proliferation of a solid nest of basaloid cells showing unclear palisading in the periphery. Marked hyperkeratosis and hypergranulosis were also seen in the adjacent dermis. Loss of the steroid sulfatase gene was found on chromosome X. Based on these finding, we made a diagnosis of X-linked recessive ichthyosis with basal cell carcinoma. To our knowledge, there has been no report of X-linked recessive ichthyosis with cutaneous malignancy. We discuss the risk of skin cancer in relation to ichthyosis.

References

Nov 1, 1995·Journal of the American Academy of Dermatology·D J ElbaumM MacDuff
Apr 27, 2011·The British Journal of Dermatology·K NatsugaH Shimizu
Jun 28, 2013·The Journal of Dermatology·Tatsuya Takenouchi, Sumiko Takatsuka
Mar 8, 2016·The Journal of Dermatology·Takuya Takeichi, Masashi Akiyama
Sep 14, 2017·Journal of Pediatric Hematology/oncology·Faruk TasFatih Goktay

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