PMID: 9555892Apr 29, 1998Paper

IS6110 transposition and evolutionary scenario of the direct repeat locus in a group of closely related Mycobacterium tuberculosis strains

Journal of Bacteriology
Z FangKen J Forbes

Abstract

In recent years, various polymorphic loci and multicopy insertion elements have been discovered in the Mycobacterium tuberculosis genome, such as the direct repeat (DR) locus, the major polymorphic tandem repeats, the polymorphic GC-rich repetitive sequence, IS6110, and IS1081. These, especially IS6110 and the DR locus, have been widely used as genetic markers to differentiate M. tuberculosis isolates and will continue to be so used, due to the conserved nature of the genome of M. tuberculosis. However, little is known about the processes involved in generating these or of their relative rates of change. Without an understanding of the biological characteristics of these genetic markers, it is difficult to use them to their full extent for understanding the population genetics and epidemiology of M. tuberculosis. To address these points, we identified a cluster of 7 isolates in a collection of 101 clinical isolates and investigated them with various polymorphic genetic markers, which indicated that they were highly related to each other. This cluster provided a model system for the study of IS6110 transposition, evolution at the DR locus, and the effects of these on the determination of evolutionary relationships among M. tuber...Continue Reading

References

Jan 1, 1975·Molecular & General Genetics : MGG·H J Reif, H Saedler
Feb 1, 1992·The Journal of Applied Bacteriology·N G FomukongJ M Grange
Dec 1, 1992·Genetics·S A Sawyer, D L Hartl
Aug 13, 1992·Nature·B R Bloom
Jun 5, 1991·Journal of Molecular Biology·S F Altschul
Jan 11, 1990·Nucleic Acids Research·D ThierryJ L Guesdon
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Karlin, S F Altschul
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·W R Pearson, D J Lipman
Mar 1, 1970·Journal of Molecular Biology·S B Needleman, C D Wunsch
Jul 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·L GreenD L Hartl
Jan 1, 1980·Molecular & General Genetics : MGG·R KlaerP Starlinger
Jan 1, 1994·Journal of Clinical Microbiology·M D CaveJ T Crawford
Jul 1, 1994·Journal of Clinical Microbiology·R FrothinghamK H Wilson
Jun 1, 1994·Molecular Microbiology·M Hernandez PerezJ W Dale
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·T LeitnerJ Albert
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·F J AyalaJ Kwiatowski
Jul 1, 1996·Journal of Clinical Microbiology·M Achtman
Feb 1, 1997·Journal of Clinical Microbiology·Z Fang, K J Forbes
Jan 1, 1997·Journal of Molecular Evolution·J TamamesA Valencia

❮ Previous
Next ❯

Citations

May 24, 2001·Current Opinion in Pulmonary Medicine·H A Fletcher
May 8, 2001·American Journal of Clinical Pathology·J A IkonomopoulosC N Kittas
Mar 9, 2002·Omics : a Journal of Integrative Biology·Rund JansenLeo M Schouls
Mar 15, 2006·Journal of Medical Microbiology·Cristina Viana-NieroSylvia Cardoso Leão
Oct 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark M Tanaka, Andrew R Francis
May 21, 2009·FEMS Microbiology Reviews·Wenjun LiPierre-Edouard Fournier
Apr 16, 2002·Molecular Microbiology·Ruud JansenLeo M Schouls
Jul 23, 1999·Annals of the New York Academy of Sciences·N V Fedoroff
May 8, 2004·Molecular Microbiology·Hassan SafiSusan T Howard
Sep 27, 2007·Environmental Microbiology·Gene W Tyson, Jillian F Banfield
Dec 3, 2008·Emerging Infectious Diseases·Keyvan TadayonKen J Forbes
Aug 17, 2006·Nature Reviews. Microbiology·Noel H SmithR Glyn Hewinson
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·E MazarsP Supply
Feb 18, 2011·Journal of Clinical Microbiology·Anita C SchürchDick van Soolingen
Nov 26, 2010·Journal of Bacteriology·Stefan BergNoel H Smith
Jan 28, 1999·Journal of Bacteriology·Z FangK J Forbes
Jul 16, 2019·Molecular Phylogenetics and Evolution·Egor ShitikovVadim Govorun
Sep 28, 2001·Journal of Clinical Microbiology·L Vera-CabreraJ Castro-Garza
Oct 2, 2002·Journal of Clinical Microbiology·R M WarrenT C Victor
Oct 12, 2016·Microbiology Spectrum·Maxime Barbier, Thierry Wirth
Apr 12, 2003·Journal of Microbiological Methods·Hasan YesilkayaKen J Forbes
Mar 5, 2010·Journal of Clinical Microbiology·Christiane HonischStefan Niemann
Jan 4, 2001·Journal of Clinical Microbiology·B M Njanpop-LafourcadeN Haddad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.