PMID: 7995994Dec 1, 1994Paper

IS6770, an enterococcal insertion-like sequence useful for determining the clonal relationship of clinical enterococcal isolates

The Journal of Infectious Diseases
A S ThorisdottirH Fraimow

Abstract

Enterococci expressing resistance to antimicrobial agents are increasingly important nosocomial pathogens. Effective strategies to prevent or abort outbreaks of resistant enterococcal infection will rely on an accurate understanding of the mechanisms by which these organisms spread. A 1065-bp insertion-like sequence (IS6770) is present in varying copy numbers in > 90% of enterococcal strains thus far examined. Hybridization patterns resulting from hybridization of enterococcal genomic DNA with an internal IS6770 probe vary considerably between unrelated strains and correlate well with results of pulsed-field gel electrophoresis and field-inversion gel electrophoresis in identifying clonal relationships among enterococcal isolates. IS6770 analysis of several outbreaks of resistant enterococci has confirmed the spread of single resistant clones rather than the emergence of resistance within the resident flora. These results suggest that IS6770 hybridization will be a useful tool for tracing the epidemiology of nosocomial enterococcal infections.

Citations

Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Louis B RiceRebecca Hutton-Thomas
Jul 19, 2006·Clinical Microbiology Reviews·Aparajita SinghMarcus J Zervos
Feb 10, 2004·Journal of Clinical Microbiology·Ok-Jin ParkKack-Kyun Kim
Feb 1, 1996·Clinical Molecular Pathology·S SethiK L Klingman
Jul 27, 2012·International Journal of Food Microbiology·Frédéric Bustos GasparMaria de Fátima Silva Lopes
Jun 24, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·K HegstadA Sundsfjord
Oct 26, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J Bedendo, A C Pignatari
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·L B RiceS D Rudin
Jun 10, 1998·Microbiology and Molecular Biology Reviews : MMBR·A van BelkumH Verbrugh

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