Isavuconazole is highly active in vitro against Candida species isolates but shows trailing effect

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Laura Judith Marcos-ZambranoJesús Guinea

Abstract

Isavuconazole is a triazole previously shown to have potent in vitro activity against Aspergillus spp., Mucorales and Candida spp. Unlike other azoles, it is unclear whether isavuconazole induces a trailing effect. We studied isavuconazole MICs for a large collection of Candida isolates from blood samples and determined the extent of the trailing effect when using the European Committee on Antimicrobial Susceptibility Testing (EUCAST) E.Def 7.3.1 method. A total of 762 molecularly identified Candida isolates from blood samples of 743 patients admitted to hospital (January 2007 to September 2017) were evaluated and further tested for in vitro susceptibility to isavuconazole following the EUCAST E.Def 7.3.1 test method. C. albicans showed the highest susceptibility, followed by C. parapsilosis and C. tropicalis (geometric mean MIC 0.0029 vs. 0.0049/0.0052, respectively; p <0.001). In contrast, C. glabrata and C. krusei had significantly higher MIC values (geometric mean MIC 0.171 vs. 0.117, respectively). Isavuconazole MIC distributions were not truncated at the lowest concentration tested except for C. albicans. Overall, the mean percentage of trailing was 13.6%, but differences among species were observed: C. glabrata, C. albic...Continue Reading

Citations

Mar 27, 2019·Antimicrobial Agents and Chemotherapy·Karin Meinike JørgensenMaiken Cavling Arendrup
Jun 3, 2021·Journal of Fungi·Juan Vicente Mulet BayonaConcepción Gimeno Cardona
Aug 27, 2021·Journal of Fungi·Pao-Yu ChenShan-Chwen Chang
Dec 23, 2021·Internal Medicine Journal·Caitlin KeighleyUNKNOWN Australasian Antifungal Guidelines Steering Committee

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