Ischaemic brain oedema

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Cenk Ayata, Allan H Ropper

Abstract

Ischaemic brain oedema appears to involve two distinct processes, the relative contribution and time course of which depend on the duration and severity of ischaemia, and the presence of reperfusion. The first process involves an increase in tissue Na+ and water content accompanying increased pinocytosis and Na+, K+ ATPase activity across the endothelium. This is apparent during the early phase of infarction and before any structural damage is evident. This phenomenon is augmented by reperfusion. A second process results from a more indiscriminate and delayed BBB breakdown that is associated with infarction of both the parenchyma and the vasculature itself. Although, tissue Na+ level still seems to be the major osmotic force for oedema formation at this second stage, the extravasation of serum proteases is an additional potentially deleterious factor. The relative importance of protease action is not yet clear, however, degradation of the extracellular matrix conceivably leads to further BBB disruption and softening of the tissue, setting the stage for the most pronounced forms of brain swelling. A number of factors mediate or modulate ischaemic oedema formation, however, most current information comes from experimental models,...Continue Reading

References

Dec 1, 1978·Anesthesiology·A L BleyaertG R Rao
May 1, 1979·Journal of Neuropathology and Experimental Neurology·C K Petito
Oct 2, 1975·The New England Journal of Medicine·R A Fishman
Nov 1, 1992·Journal of Neurobiology·D W Choi
Aug 3, 1992·Neuroscience Letters·Y YamasakiK Kogure
Dec 1, 1992·Stroke; a Journal of Cerebral Circulation·J M Wardlaw, C P Warlow
Oct 1, 1992·Journal of Neurosurgery·A M Kaufmann, E R Cardoso
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H KinouchiP H Chan
Apr 29, 1991·Neuroscience Letters·Y ShigaF Sendo
Nov 1, 1990·Archives of Neurology·J M Hallenbeck, A J Dutka
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U Dirnagl, W Pulsinelli
May 1, 1990·Stroke; a Journal of Cerebral Circulation·A SlivkaW Pulsinelli
Jan 1, 1990·Free Radical Biology & Medicine·O UyamaM Sugita
Jun 1, 1990·Stroke; a Journal of Cerebral Circulation·J B DelashawM S Grady
Aug 1, 1990·Stroke; a Journal of Cerebral Circulation·M LimburgB W Verbeeten
Aug 1, 1990·Stroke; a Journal of Cerebral Circulation·A L Betz, H C Coester
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B K Siesjö, F Bengtsson
Jul 1, 1989·Critical Care Medicine·T E Emerson
Jan 1, 1989·British Journal of Clinical Pharmacology·G Waldemar, O B Paulson
Aug 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B GrøgaardK E Arfors
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S YamaguchiM Kitani
Apr 1, 1988·Stroke; a Journal of Cerebral Circulation·K AbeK Kogure
Jan 4, 1986·British Medical Journal·J W Norris, V C Hachinski
Dec 17, 1988·BMJ : British Medical Journal·P J KoudstaalM Vermeulen
Jan 1, 1988·Acta Neuropathologica·K FredrikssonY Olsson
Jan 1, 1988·Stroke; a Journal of Cerebral Circulation·S Hatashita, J T Hoff

❮ Previous
Next ❯

Citations

May 1, 2009·Acta Neuropathologica·Sukriti NagDuncan J Stewart
May 21, 2010·PloS One·Svitlana Garbuzova-DavisPaul R Sanberg
May 22, 2013·PloS One·Cesar A GonzalezBoris Rubinsky
Jul 7, 2007·Neurosurgical Focus·Danny LiangJ Marc Simard
Dec 17, 2011·International Journal of Molecular Sciences·Kiran S Panickar, Richard A Anderson
Apr 19, 2007·Neurological Research·John W CalvertJohn H Zhang
Jul 3, 2013·International Journal of Inflammation·Kate Marie LewisRobert Vink
May 24, 2012·Cellular and Molecular Life Sciences : CMLS·Timo Kahles, Ralf P Brandes
Nov 4, 2015·Journal of Neurotrauma·Shuzhen GuoEng H Lo
May 5, 2009·Annals of Medicine·Daniel StrbianPerttu J Lindsberg
Jan 1, 2013·Progress in Neurobiology·Christiane Albert-WeißenbergerChristoph Kleinschnitz
Oct 19, 2010·Travel Medicine and Infectious Disease·Alex Baneke
Jan 30, 2010·Behavioural Brain Research·Jianping WangYujin Hao
Apr 9, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Amy C Y LoSookja K Chung
Dec 3, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Sai-Cheung LeePo-Jen Chen
Jan 8, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Craig M McKittrickHilary V O Carswell
Nov 12, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sophia L GoerickeArnd Doerfler
Sep 16, 2008·Neurobiology of Disease·Karin E Sandoval, Ken A Witt
May 22, 2007·Brain Research·Svitlana Garbuzova-DavisPaul R Sanberg
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Arne Lindgren, Jan Malm
Mar 13, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Daniel StrbianUNKNOWN Helsinki Stroke Thrombolysis Registry Group
Aug 8, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·P MichelUNKNOWN Swiss Working Group of Cerebrovascular Diseases with the Swiss Society of Neurosurgery and the Swiss Society of Intensive Ca
Aug 12, 2009·Annals of Neurology·Muhammad S HussainChristian Beaulieu
Apr 18, 2007·Journal of Neurochemistry·Inmaculada RiteJosé L Venero
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Christine PreibischRalf Deichmann
Dec 7, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Steffen VolzRalf Deichmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.