PMID: 8582377Sep 1, 1995Paper

Ischaemic preconditioning: is it clinically relevant?

European Heart Journal
P D VerdouwD J Duncker

Abstract

Direct clinical evidence for the classical preconditioning phenomenon, with infarct size limitation as an endpoint, cannot be obtained. However, a number of patient groups have been identified in which adaptation to ischaemia has been demonstrated by enhanced recovery of function or preservation of high energy phosphates in models of repeated ischaemia, such as atrial pacing stress tests, percutaneous transluminal coronary angioplasty and aortic cross-clamping during cardiac surgery. Evidence is accumulating that mechanisms which are operative in experimental ischaemic preconditioning (infarct size limitation) are also operative in these clinical models of repeated reversible ischaemia. Insight into the mechanisms responsible for ischaemic preconditioning could potentially help to develop pharmacological agents which mimic preconditioning. This is especially attractive as several of the ischaemic episodes maybe too short or insufficiently severe to trigger preconditioning. By a synergistic or additive action, the combination of such a stimulus with a low dose of pharmacological agent might result in protective action. If these agents were also to be used for treating cardiovascular conditions, such as the K+ATP channel activato...Continue Reading

Citations

Oct 16, 2010·Cardiovascular Therapeutics·Ronen Durst, Chaim Lotan
Nov 1, 1996·Circulation·B C GhoP D Verdouw
Jul 23, 1999·Annals of the New York Academy of Sciences·S de ZeeuwP D Verdouw
Apr 11, 2002·Acta Anaesthesiologica Scandinavica·Hilchen T Sommerschild, Knut Arvid Kirkebøen
Aug 17, 1999·Current Opinion in Cardiology·E R SchwarzR A Kloner

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