Ischemia and reperfusion increases susceptibility to ventilator-induced lung injury in rats

American Journal of Respiratory and Critical Care Medicine
Ettore CrimiA S Slutsky

Abstract

Hemorrhagic shock followed by resuscitation (HSR) commonly triggers an inflammatory response that leads to acute respiratory distress syndrome. HSR exacerbates mechanical stress-induced lung injury by rendering the lung more susceptible to ventilator-induced lung injury. Rats were subjected to HSR, and were randomized into an HSR + high tidal volume and zero positive end-expiratory pressure (PEEP) or a HSR + low tidal volume with 5 cm H(2)O PEEP. A sham-operated rat + high tidal volume and zero PEEP served as a control. HSR increased susceptibility to ventilator-induced lung injury as evidenced by an increase in lung elastance and the wet/dry ratio and a reduction in Pa(O(2)) as compared with the other groups. The lung injury observed in the HSR + high tidal volume group was associated with a higher level of interleukin 6 in the lung and blood, increased epithelial cell apoptosis in the kidney and small intestine villi, and a tendency toward high levels of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and creatinine in plasma. HSR priming renders the lung and kidney more susceptible to mechanical ventilation-induced organ injury.

References

Jan 1, 1977·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S M Cain
Jun 1, 1992·Journal of Cardiovascular Pharmacology·B ZingarelliA P Caputi
Jan 1, 1991·The American Journal of Physiology·A AyalaI H Chaudry
May 1, 1991·The American Review of Respiratory Disease·K TsunoT Morioka
Oct 1, 1987·British Journal of Anaesthesia·E P ArgirasM K Sykes
Jan 1, 1994·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·E N Wardle
Mar 1, 1994·American Journal of Respiratory Cell and Molecular Biology·R ShenkarE Abraham
Apr 1, 1994·The American Journal of Physiology·B ZingarelliA P Caputi
Jan 1, 1997·American Journal of Respiratory and Critical Care Medicine·E E DouzinasC Roussos
Mar 1, 1997·The Journal of Clinical Investigation·L TremblayA S Slutsky
Nov 14, 1997·American Journal of Respiratory and Critical Care Medicine·D De BackerJ L Vincent
Jan 28, 1998·American Journal of Respiratory and Critical Care Medicine·A N von BethmannS Uhlig
Sep 5, 1998·The American Journal of Physiology·C HierholzerD J Tweardy
Mar 4, 1999·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·R PararajasingamR D Sayers
Mar 24, 1999·The Journal of Trauma·M A CroceT J Gavin
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·D ChiumelloA S Slutsky
Jul 17, 1999·The American Journal of Physiology·N E VlahakisR D Hubmayr
Aug 14, 1999·Critical Care Medicine·R S HotchkissI E Karl
May 4, 2000·The New England Journal of Medicine·UNKNOWN Acute Respiratory Distress Syndrome NetworkArthur Wheeler
Jun 29, 2000·JAMA : the Journal of the American Medical Association·V M RanieriA S Slutsky
Aug 3, 2000·Intensive Care Medicine·C C dos Santos, A S Slutsky
Sep 28, 2000·Journal of Applied Physiology·C C Dos Santos, A S Slutsky
Feb 24, 2001·American Journal of Physiology. Cell Physiology·Z H MengD J Tweardy
Jun 30, 2001·The New England Journal of Medicine·M J Tobin
Aug 16, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·Y SongX Meng
Aug 6, 2002·Respiratory Physiology & Neurobiology·Fabienne BrégeonYves Jammes

❮ Previous
Next ❯

Citations

Jul 31, 2008·Critical Care Medicine·Alexander B Adams, Jerónimo Graf
Jun 3, 2009·Critical Care Medicine·Chin-Ming ChenArthur S Slutsky
May 25, 2010·The Journal of Trauma·Vincenzo CannizzaroPeter D Sly
Mar 27, 2007·American Journal of Respiratory and Critical Care Medicine·Eric B MilbrandtDerek C Angus
Apr 24, 2010·American Journal of Respiratory and Critical Care Medicine·Ali AkramClaudia C dos Santos
Sep 28, 2010·American Journal of Respiratory and Critical Care Medicine·Claudia C dos dos SantosJack J Haitsma
Sep 3, 2011·Critical Care : the Official Journal of the Critical Care Forum·Jan Willem KuiperA B Johan Groeneveld
Mar 30, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rosanna VaschettoFrans B Plötz
Nov 6, 2012·The Journal of Surgical Research·Karlijn J P van WessemLuke P H Leenen
Apr 4, 2008·Experimental Neurology·Denis GrisLynne C Weaver
Sep 11, 2016·Pulmonary Pharmacology & Therapeutics·Janiana Raíza Jentsch Matias de OliveiraEunice André
Mar 8, 2014·Expert Review of Respiratory Medicine·Yuda SutherasanPaolo Pelosi
Dec 8, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Nagaraja NagreXiaoli Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.