Ischemia-induced exocytosis of Weibel-Palade bodies mobilizes stem cells.

Journal of the American Society of Nephrology : JASN
Mei-Chuan KuoM S Goligorsky

Abstract

Recruitment of various stem and progenitor cells is crucial for the regeneration of an injured organ. Levels of uric acid, one of the prototypical "alarm signals," surge after ischemia-reperfusion injury. Exogenous uric acid rapidly mobilizes endothelial progenitor cells and hematopoietic stem cells and protects the kidney from ischemia. The relatively fast responses to uric acid suggest that preformed second messengers may be released from a storage pool. Here, it is reported that monosodium urate (MSU) results in exocytosis of Weibel-Palade bodies in vitro and in vivo, leading to the release of IL-8, von Willebrand factor, and angiopoietin 2 in the culture medium or circulation. Confocal and immunoelectron microscopy confirmed depletion of von Willebrand factor in MSU-treated aortic endothelial cells. Angiopoietin 2 alone induced exocytosis of Weibel-Palade bodies, mobilized hematopoietic stem cells and depleted splenic endothelial progenitor cells, partially reproducing the actions of MSU. In addition, pretreatment with angiopoietin 2 protected the kidneys from an ischemic insult, suggesting that the previously reported renoprotection conferred by MSU likely results from exocytosis of Weibel-Palade bodies. Furthermore, exper...Continue Reading

References

Nov 6, 1998·The Journal of Experimental Medicine·J O UtgaardG Haraldsen
Apr 16, 2002·Science·Polly Matzinger
Sep 4, 2004·Blood·Kenji MatsushitaCharles J Lowenstein
Apr 9, 2005·Journal of Leukocyte Biology·Leigh D ChurchStephen P Young
May 5, 2005·The Journal of Pharmacology and Experimental Therapeutics·Fiorentina RoviezzoAndreas Papapetropoulos
Sep 1, 2005·Biochemical and Biophysical Research Communications·Kathryn A Gill, Nicholas P J Brindle
Nov 22, 2005·Trends in Cardiovascular Medicine·Charles J LowensteinMunekazu Yamakuchi
Feb 16, 2006·American Journal of Physiology. Renal Physiology·Daniel PatschanMichael S Goligorsky
May 23, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Rania Harfouche, Sabah N A Hussain
Oct 4, 2006·Circulation·Jeffrey M Zimmet, Joshua M Hare
Oct 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher DalyJohn S Rudge
Oct 13, 2006·Journal of Leukocyte Biology·Marco E Bianchi
Nov 7, 2006·Nature Medicine·Vineet BhandariJack A Elias
Jan 18, 2007·The Journal of Biological Chemistry·Takeshi IntoKenji Matsushita
Apr 6, 2007·Journal of the American Society of Nephrology : JASN·Daniel PatschanMichael S Goligorsky

❮ Previous
Next ❯

Citations

Jun 27, 2009·Nature Reviews. Nephrology·Michael S GoligorskyMei-Chuan Kuo
Oct 20, 2009·Current Opinion in Nephrology and Hypertension·Adrian S Woolf
May 16, 2009·Nephrology·Michael S GoligorskyMarianne C Verhaar
Dec 23, 2011·American Journal of Physiology. Renal Physiology·May M RabadiBrian B Ratliff
Dec 14, 2011·American Journal of Physiology. Renal Physiology·Kaoru YasudaMichael S Goligorsky
Mar 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Susann A PatschanGerhard A Müller
Jun 4, 2014·Nature Reviews. Nephrology·Jaklien C LeemansSandrine Florquin
May 24, 2012·Seminars in Nephrology·Sergey V Brodsky, Michael S Goligorsky
Mar 10, 2016·Critical Care : the Official Journal of the Critical Care Forum·Tobias HilbertMarkus Velten
May 6, 2015·Prostaglandins & Other Lipid Mediators·Joseph ZulloMichael S Goligorsky
May 23, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Cleofina BoscoRamón Rodrigo
Dec 4, 2014·Cytokine & Growth Factor Reviews·Tobias Hilbert, Sven Klaschik
May 24, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jong Wook SongMichael S Goligorsky
Feb 22, 2011·Journal of the American Society of Nephrology : JASN·Diane L Rosin, Mark D Okusa
Feb 24, 2018·Journal of the American Society of Nephrology : JASN·Jason H GreenbergChirag R Parikh
Apr 17, 2010·Journal of the American Society of Nephrology : JASN·Michael S GoligorskyBrian Ratliff
Jan 26, 2013·Journal of the American Society of Nephrology : JASN·Brian B RatliffMichael S Goligorsky
May 6, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kazuyo Yamaji-KeganRoger A Johns
May 23, 2019·Canadian Journal of Physiology and Pharmacology·Dina M KhodeerAmani A Elbaz
Apr 1, 2020·American Journal of Physiology. Renal Physiology·Su Woong JungJu-Young Moon
Apr 6, 2018·Korean journal of anesthesiology·Jong Wook Song, Michael S Goligorsky
Aug 28, 2020·Frontiers in Medicine·Aprajita GuptaVeena Puri
Mar 10, 2021·Blood Advances·Noor F ShaikUlhas P Naik
Feb 10, 2020·The American Journal of Pathology·Michael S Goligorsky, Dong Sun
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying XinTao Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.