Ischemia modified albumin: an oxidative stress marker in β-thalassemia major

Clinica Chimica Acta; International Journal of Clinical Chemistry
Samir M AwadallahSuleiman A Saleh

Abstract

Ischemia modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress. This study reports on the levels and clinical significance of IMA in patients with β-thalassemia major. Blood specimens were collected from 166 subjects (101 β-thalassemia major patients and 65 healthy controls). Serum levels of IMA, ferritin, malondialdehyde (MDA), ferroxidase, transaminases, total protein, and albumin were determined using conventional methods. Serum levels of IMA (ABSU) were significantly higher in patients than in controls (0.725±0.155 vs 0.554±0.154, p=0.000). Similarly, higher levels were also observed for ferritin, MDA, ferroxidase, and transaminases. No significant differences were observed between patients and controls with respect to total protein and albumin. Spearman univariate analysis demonstrated significant correlation between IMA and ferritin, MDA, ferroxidase, and transaminases. Multiple linear regression analysis revealed significant association of IMA with ferritin and ferroxidase after adjusting for the other variables (r=0.343, p=0.002; r=0.228, p=0.029 respectively). MDA however, correlated significantly with ferritin only (r=0.654, p=0.000). Our findings suggest that incre...Continue Reading

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Citations

May 10, 2013·Critical Reviews in Toxicology·Dennis J PaustenbachBrent D Kerger
Jun 10, 2017·Biomarkers in Medicine·Hatice AtaşMustafa Kavutçu
Jun 18, 2019·Journal of Pediatric Hematology/oncology·Işik Odaman AlÖzcan Erel
Sep 15, 2018·International Journal of Endocrinology and Metabolism·Iraj ShahramianAlireza Sargazi
Mar 16, 2017·Redox Report : Communications in Free Radical Research·Amira Abdel Moneam AdlySara Hamed Elmetwally
Feb 2, 2021·Journal of Diabetes and Metabolic Disorders·Soheila SetoodehMohammad Ali Takhshid

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