Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesia

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
T AnneckePeter Conzen

Abstract

Vascular leakage after ischemia-reperfusion (IR) is largely attributed to the destruction of the endothelial barrier and its associated negatively charged glycocalyx. In vitro, sevoflurane attenuates these changes. Therefore, we compared sevoflurane with propofol with regard to the protection of the glycocalyx and the release of negatively charged substances in vivo. After surgical preparation under midazolam-fentanyl, nine pigs each received either propofol or sevoflurane. Ischemia of 90 min was induced by a balloon catheter in the thoracic aorta. After 120 min of reperfusion, the anesthetics were changed back to midazolam-fentanyl. Five animals, each without aortic occlusion, served as time controls. Blood electrolyte parameters were measured, from which the strong ion gap (SIG) was calculated. Serum heparan sulfate concentrations and immunohistology served as a marker of glycocalyx destruction. Immediately after reperfusion, SIG increased significantly only in the propofol group (+6.7 mEq/l versus baseline; p < .05), remaining stable in sevoflurane and both time-controlled groups. Initially, heparan sulfate concentration increased comparably in both experimental groups, but after 120 min, it became stable in sevoflurane-anes...Continue Reading

References

Jun 1, 1995·Journal of Critical Care·J A KellumM R Pinsky
Sep 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·A W Mulivor, H H Lipowsky
Jan 6, 2004·American Journal of Physiology. Heart and Circulatory Physiology·A W Mulivor, H H Lipowsky
Jan 8, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Gernot M KaiserChristoph E Broelsch
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Lewis J Kaplan, Spiros Frangos
Apr 29, 2005·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Andrew DurwardIan A Murdoch
Nov 10, 2005·Critical Care : the Official Journal of the Critical Care Forum·Lui G ForniPhilip J Hilton
Jan 10, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ivan Rubio-GayossoBrian R Duling
Sep 27, 2006·Handbook of Experimental Pharmacology·A R Pries, W M Kuebler
Dec 13, 2007·Anesthesiology·Daniel ChappellBernhard F Becker
Dec 18, 2007·Critical Care : the Official Journal of the Critical Care Forum·Dirk BrueggerMarkus Rehm
May 15, 2008·Acta Anaesthesiologica Scandinavica·T AnneckeP F Conzen
Jul 11, 2008·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jeong-Sang LeeYong-Joo Kim
Sep 24, 2008·Der Anaesthesist·D ChappellM Rehm
Oct 7, 2008·Basic Research in Cardiology·Daniel ChappellBernhard F Becker
Jun 30, 2009·The Journal of Surgical Research·Jochen SteppanMarkus A Weigand
Feb 23, 2010·British Journal of Anaesthesia·T AnneckeB F Becker
Mar 5, 2010·Cardiovascular Research·J Rodney Levick, C Charles Michel
May 14, 2010·Cardiovascular Research·Bernhard F BeckerMatthias Jacob
Jun 15, 2010·Cardiovascular Research·Fitz-Roy E Curry, Thomas Noll

❮ Previous
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Citations

May 30, 2015·International Journal of Molecular Sciences·Ming-Chung LinChung-Hsi Hsing
Sep 22, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Vinzent N SpetzlerMarkus Selzner
Apr 30, 2014·Anaesthesia·C S Alphonsus, R N Rodseth
Sep 3, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jan M KnaakMarkus Selzner
Jan 20, 2015·Acta Anaesthesiologica Scandinavica·J A Kolsen-Petersen
May 8, 2014·Mediators of Inflammation·Hana KolářováLukáš Kubala
Oct 27, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nicolas GoldaracenaMarkus Selzner
May 31, 2013·Seminars in Cardiothoracic and Vascular Anesthesia·Edmond Hung Leong Chau, Peter Slinger
Jul 12, 2017·Shock·Nikolaus HofmannHerbert Schöchl
Mar 5, 2019·Chinese Medical Journal·Rui-Na CaoRui Xia
Jan 23, 2016·Anesthesia and Analgesia·José A AguirreMichael Zaugg
Mar 13, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Junjie ZhangShaoliang Chen
Sep 30, 2017·Critical Reviews in Clinical Laboratory Sciences·Vladimir CernyZdenek Zadak
Jul 11, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Marius RoaldsenErling Aarsaether
Sep 13, 2016·Journal of Intensive Care·Akira UshiyamaTakehiko Iijima
Apr 9, 2019·Chinese Medical Journal·Rui-Na CaoRui Xia
Feb 29, 2020·World Journal of Transplantation·Julianna E BuchwaldPaulo N Martins
Feb 10, 2020·The American Journal of Pathology·Zaid AbassiSamuel N Heyman
Apr 4, 2021·International Journal of Molecular Sciences·Gertrude J Nieuwenhuijs-MoekeHenri G D Leuvenink
May 3, 2021·Journal of Clinical Monitoring and Computing·Matheus Golenia Dos PassosMárcio Manozzo Boniatti
May 25, 2021·Frontiers in Veterinary Science·Lisa Smart, Dez Hughes

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