Ischemia-reperfusion injury leads to distinct temporal cardiac remodeling in normal versus diabetic mice.

PloS One
Megumi EguchiGary Sweeney

Abstract

Diabetes is associated with higher incidence of myocardial infarction (MI) and increased propensity for subsequent events post-MI. Here we conducted a temporal analysis of the influence of diabetes on cardiac dysfunction and remodeling after ischemia reperfusion (IR) injury in mice. Diabetes was induced using streptozotocin and IR performed by ligating the left anterior descending coronary artery for 30 min followed by reperfusion for up to 42 days. We first evaluated changes in cardiac function using echocardiography after 24 hours reperfusion and observed IR injury significantly decreased the systolic function, such as ejection fraction, fractional shortening and end systolic left ventricular volume (LVESV) in both control and diabetic mice. The longitudinal systolic and diastolic strain rate were altered after IR, but there were no significant differences between diabetic mice and controls. However, a reduced ability to metabolize glucose was observed in the diabetic animals as determined by PET-CT scanning using 2-deoxy-2-((18)F)fluoro-D-glucose. Interestingly, after 24 hours reperfusion diabetic mice showed a reduced infarct size and less apoptosis indicated by TUNEL analysis in heart sections. This may be explained by inc...Continue Reading

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Citations

Aug 29, 2014·Cardiovascular Diabetology·Augustin DuSablonJitka Virag
Sep 27, 2012·The Journal of Pathology·David M Ansley, Baohua Wang
Apr 1, 2017·Nature Reviews. Cardiology·Lea M D DelbridgeRoberta A Gottlieb
May 8, 2018·Hypertension·Xiuchuan LiYongjian Yang
Mar 22, 2014·Biomedical Reports·Xiao-Fang TianDA-Yi Hu
Jun 1, 2018·BioMed Research International·Chunmiao LuJunping Zhang
Mar 10, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Lea M D DelbridgeRoberta A Gottlieb
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Namrita KaurWei Liu

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