Ischemic acute renal failure following nephrectomy impairs long-term renal function

Transplantation
Alkesh JaniCharles L Edelstein

Abstract

Uninephrectomy is associated with increased glomerular filtration rate in both the donated and the remaining contralateral kidney. The long-term effects of ischemic acute renal failure (ARF) following uninephrectomy are unknown. This study examined renal function, histology and proteinuria 52 weeks after an episode of reversible ischemic ARF. Ischemic ARF was induced in uninephrectomised mice by renal pedicle clamping. At 52 weeks inulin clearance (muL/min/g) was 7.2+/-0.2 in sham, 5.0+/-0.1 in uninephrectomy (P<0.01 vs. sham) and 3.9+/-0.1 in uninephrectomy + ischemia (P<0.01 vs. sham, P<0.05 vs. uninephrectomy). Thus, mice subjected to uninephrectomy alone demonstrated compensatory hyperfiltration following reduction in renal mass. This response was prevented by ischemic ARF. At 52 weeks there was no difference in urine protein/creatinine, mean arterial pressure or scores of glomerulosclerosis or interstitial fibrosis. In conclusion, ischemic ARF following uninephrectomy in mice impairs long-term renal function.

References

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Citations

Jun 21, 2008·Advances in Chronic Kidney Disease·Sri G YarlagaddaAlkesh Jani
Oct 8, 2014·Journal of Cellular and Molecular Medicine·Clintoria R WilliamsJennifer L Gooch
Jun 4, 2019·The Journal of Pharmacology and Experimental Therapeutics·Bagna BaoJeffrey D Peterson
Nov 14, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Su SongOliver Witzke

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