PMID: 9434704Jan 22, 1998Paper

Ischemic and reperfusion injury of cyanotic myocardium in chronic hypoxic rat model: changes in cyanotic myocardial antioxidant system

The Journal of Thoracic and Cardiovascular Surgery
K NakanishiS Sano

Abstract

The objective was to evaluate the effect of left ventricular function on cyanotic myocardium after ischemia-reperfusion and to determine the effect of cyanosis on the myocardial antioxidant system. Cyanotic hearts (cyanotic group) were obtained from rats housed in a hypoxic chamber (10% oxygen) for 2 weeks and control hearts (control group) from rats maintained in ambient air. Isolated, crystalloid perfused working hearts were subjected to 15 minutes of global normothermic ischemia and 20 minutes of reperfusion, and functional recovery was evaluated in the two groups. Myocardial superoxide dismutase, glutathione peroxidase, glutathione reductase activity, and reduced glutathione content were measured separately in the cytoplasm and mitochondria at the end of the preischemic, ischemic, and reperfusion periods. Mean cardiac output/left ventricular weight was not significantly different between the two groups. Percent recovery of cardiac output was significantly lower in the cyanotic group than in the control group (56.1% +/- 5.7% vs 73.0% +/- 3.1%, p = 0.001). Mitochondrial superoxide dismutase, mitochondrial and cytosolic glutathione reductase activity, and cytosolic reduced glutathione were significantly lower in the cyanotic g...Continue Reading

References

Oct 1, 1992·Journal of Molecular and Cellular Cardiology·H L WaltersJ W Kirklin
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Citations

Sep 18, 2010·Calcified Tissue International·Takeshi MatsumotoKentaro Uesugi
Apr 20, 2010·General Thoracic and Cardiovascular Surgery·Yasuhiro FujiiShunji Sano
Jan 17, 2004·The Annals of Thoracic Surgery·Kenji SangawaShunji Sano
Aug 16, 2005·Brain Research. Developmental Brain Research·Lakshmi RamanRaghavendra Rao
Aug 5, 2000·The Journal of Thoracic and Cardiovascular Surgery·M NagashimaJ E Mayer

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