Ischemic brain edema: comparative effects of barbiturates and hypothermia

Stroke; a Journal of Cerebral Circulation
F A SimeoneP Lawner

Abstract

The effect of pentobarbital and hypothermia on the development of ischemic brain edema was studied in 23 rhesus monkeys undergoing transorbital middle cerebral artery occlusion. Fifteen additional animals served as unclipped controls. Regional cortical cerebral blood flow (rCBF), arteriovenous oxygen content difference (AVDO2), and regional cortical metabolic rate of O2 (rCMRO2) were measured hourly until sacrifie 11 hours postocclusion, at which time ischemic cerebral edema was measured. In 8 animals no treatment followed the occlusion, and these developed edema. In 7 animals pentobarbial 14 mg/kg was administered intravenously 30 min after occlusion and 7 mg/kg every 2 hours thereafter. In this group ischemic brain edema was negligible. In 8 animals, hypothermia to 25.9 +/- 0.5 degrees C was started 30 min after occlusion and maintained until sacrifice; ischemic brain edema was not significantly altered from untreated-clipped animals. On the basis that both pentobarbital and hypothermia produced similar changes in rCBF, AVDO2, and rCMRO2, but only pentobarbital prevented edema, it is postulated that the mode of action of barbiturates in preventing ischemic brain edema is not entirely related to their known effect on blood flo...Continue Reading

References

Jan 1, 1975·Acta Anaesthesiologica Scandinavica·L NilssonR Busto
Jul 1, 1976·Anesthesiology·A L Smith, J J Marque
Nov 1, 1972·Stroke; a Journal of Cerebral Circulation·F M YatsuP Lindquist
Nov 1, 1973·Anesthesiology·J D Michenfelder, R A Theye
Sep 14, 1959·Annals of the New York Academy of Sciences·H L ROSOMOFF

Citations

Jan 1, 1989·Neurosurgical Review·K A Hossmann
Apr 1, 1989·Molecular and Chemical Neuropathology·T AsanoK Takakura
Oct 2, 2007·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shuji NiikawaTakeshi Ito
Nov 13, 2001·Clinical and Experimental Pharmacology & Physiology·J K Callaway
Mar 1, 1982·Archives of Disease in Childhood·N W SvenningsenH Ahlström
Nov 1, 1996·Neurosurgery·C L TaylorR A Ratcheson
Apr 1, 1982·Journal of Neurosurgery·J P LaurentE Fink
Apr 1, 1982·Journal of Neurosurgery·E H OldfieldW F Meacham
Apr 1, 1984·Journal of Neurosurgery·E A Frost
Nov 1, 1986·Journal of Neurosurgery·J T Hoff
May 1, 1982·Surgical Neurology·J P LaurentL B Rorke
Nov 1, 1979·Prostaglandins and Medicine·K L BlackW E Lands
Sep 1, 1983·The American Journal of Emergency Medicine·K A Hossmann
Jul 1, 1994·Resuscitation·L C CancioF Zimba
Mar 1, 1980·Anaesthesia·M Belopavlovic, A Buchthal
Sep 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K A Hossmann
Jul 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H ChenJ H Garcia
May 1, 1992·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E MorikawaR Busto
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M ChoppK M Welch
Feb 1, 1986·Anaesthesia and Intensive Care·R G HicksD A Horton
Nov 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M L SchwartzD F Andrews

Related Concepts

Metazoa
Anthropoidea
Vasogenic Cerebral Edema
Insula of Reil
Brain Ischemia
Cerebrovascular Circulation
Energy Metabolism
Mild Hypothermia, Induced
Macaca mulatta
Dioxygen

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