Ischemic cerebral tissue response to subventricular zone cell transplantation measured by iterative self-organizing data analysis technique algorithm

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Lian LiMichael Chopp

Abstract

To investigate the changes of the ischemic lesion in rat brain after subventricular zone (SVZ) cell transplantation and the influence of the grafted cells on the appearance of angiogenesis, SVZ cells, superparamagnetically labeled, were intracisternally transplanted into the rat brain 48 h after onset of embolic stroke. A complete set of magnetic resonance (MR) images was acquired for all animals with (n=8) and without (n=3) cell grafting at approximately 24 h, 72 h, and weekly for 6 weeks after stroke. Transplanted cells were tracked by high-resolution three-dimensional gradient-echo images and the interaction between the cells and ischemic lesion was detected by ISODATA (Iterative Self-Organizing Data Analysis Technique Algorithm) calculated from T(1), T(2) and T(1sat) maps. Tissue status from ISODATA was characterized by a specific signature, which represents the deviation from normal tissue in the feature space. Transplanted SVZ cells selectively migrated towards the ischemic side of the rat brain and approached the lesion boundary within 1-week after grafting. Cell treated rats exhibited a significant reduction of average lesion size compared with control rats (P<0.05). A significant reduction of tissue signature (P<0.001)...Continue Reading

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Citations

Oct 15, 2010·Journal of Neural Transmission·Yu Luo
Jun 17, 2010·Angiogenesis·Peter R SeevinckRick M Dijkhuizen
May 24, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Preeti Sahota, Sean I Savitz
Mar 22, 2008·Stroke; a Journal of Cerebral Circulation·Guangliang DingMichael Chopp
Oct 25, 2008·Regenerative Medicine·Robert H AndresRaphael Guzman
Oct 14, 2009·Neurobiology of Disease·Tonya M BlissGary K Steinberg
Apr 21, 2009·Lancet Neurology·Zheng Gang Zhang, Michael Chopp
May 12, 2009·Neuroscience Research·Miyeoun SongByung-Woo Yoon
Jul 12, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lian LiQuan Jiang
Sep 4, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Asamoah BosomtwiMichael Chopp
Jan 31, 2007·Stroke; a Journal of Cerebral Circulation·Michael ChoppQuan Jiang
Jan 29, 2019·Frontiers in Neuroscience·Christiane L MallettErik M Shapiro

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