Ischemic colitis diagnosed by magnetic resonance imaging during lenalidomide treatment in a patient with relapsed multiple myeloma

Tumori
Susanna GuerriniMaria Antonietta Mazzei

Abstract

Multiple myeloma is the second most common hematological neoplasm that also affects young patients. The progression-free survival after autologous stem cell transplant has improved with the introduction of several novel agents such as lenalidomide, which may, however, increase the risk of adverse events. We describe the case of a 54-year-old woman with relapse of multiple myeloma 3 years after myeloablative allogeneic stem cell transplant who developed abdominal pain and bloody diarrhea following 7 months of lenalidomide therapy. Abdominal plain x-ray and magnetic resonance imaging (MRI) without intravenous contrast material showed left-sided and splenic flexure acute ischemic colitis with reperfusion phenomena. Continuous intravenous infusion of unfractionated heparin was given with metronidazole and meropenem and the patient improved within a few days. MRI performed 15 days later confirmed complete recovery of ischemic colitis. To our knowledge there have been no previously reported cases of ischemic colitis during lenalidomide therapy as a single agent in relapsed or refractory multiple myeloma, in particular promptly diagnosed by MRI.

References

May 6, 1999·Radiology·E J BalthazarR B Gordon
Dec 21, 2007·Leukemia·A PalumboUNKNOWN International Myeloma Working Group
Jul 3, 2009·Cleveland Clinic Journal of Medicine·Kareem ElderFiras Al Solaiman
Jan 21, 2012·Journal of Computer Assisted Tomography·Maria Antonietta MazzeiLuca Volterrani
Mar 14, 2013·World Journal of Gastroenterology : WJG·Maria Antonietta MazzeiLuca Volterrani
Aug 2, 2013·Critical Ultrasound Journal·Maria Antonietta MazzeiLuca Volterrani
Aug 2, 2013·Critical Ultrasound Journal·A ReginelliR Grassi
Sep 24, 2014·BioMed Research International·Francesca IacobellisRoberto Grassi

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Citations

Nov 24, 2018·Alimentary Pharmacology & Therapeutics·Ziga VodusekLawrence J Brandt
Feb 26, 2020·Digestive Diseases and Sciences·Maria Antonietta MazzeiLuca Volterrani
Aug 2, 2020·Abdominal Radiology·Giulia LassandroFrancesco Lassandro
May 4, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shadi HamdehStephen Hanauer
Apr 4, 2021·Abdominal Radiology·Alfonso ReginelliSalvatore Cappabianca

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