Ischemic fasciitis: analysis of 44 cases indicating an inconsistent association with immobility or debilitation

The American Journal of Surgical Pathology
Bernadette Liegl, Christopher D M Fletcher

Abstract

Ischemic fasciitis is a rare pseudosarcomatous proliferation of atypical fibroblasts described to be located over bony protuberances and said to develop most often in immobile elderly or debilitated patients. We report the clinicopathologic features of 44 cases of this pseudosarcomatous reactive fibroblastic/myofibroblastic proliferation. There were 15 female and 29 male patients between 23 and 96 years of age (median: 74 y). Tumor size, known in 34 cases, ranged from 1.3 to 10 cm (median: 4.7 cm). The lesions developed mostly in the deep subcutis (27 cases) and infiltration of deep dermis, muscle, and tendinous tissue was sometimes observed. In 3 cases, the lesion developed within skeletal muscle. In 33 cases (76.7%), the tumor was located around the limb girdles and sacral region; 5 tumors each (23.3%) occurred on the chest wall and the back. A history of physical debilitation could be confirmed in only 7 patients. Nine patients had a history of chronic or malignant diseases and 4 patients had a history of local trauma. The histologic hallmark of this reactive proliferation is a zonal appearance with central fibrinoid degeneration/necrosis and cystic changes surrounded by a granulation tissuelike vascular component, mixed wit...Continue Reading

References

Oct 1, 1975·Cancer·E B Chung, F M Enzinger
Jul 1, 1992·The American Journal of Surgical Pathology·E A MontgomeryF M Enzinger
Oct 1, 1991·The American Journal of Surgical Pathology·E A Montgomery, J M Meis
Apr 1, 1996·The American Journal of Surgical Pathology·T MentzelC D Fletcher
Mar 1, 1997·Acta Cytologica·B S KendallP H Solanki
Apr 29, 1998·Journal of Cutaneous Pathology·M F BaldassanoT J Flotte
May 20, 1998·Pathology International·M YamamotoR Machinami
Jun 15, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M A FurlongJ C Fanburg-Smith
Mar 7, 2002·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M Fukunaga
Dec 12, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R ScanlonW G McCluggage
Oct 24, 2006·AJR. American Journal of Roentgenology·Hakan IlaslanMurali Sundaram

❮ Previous
Next ❯

Citations

Jun 16, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Munir R TanasBrian P Rubin
Dec 3, 2015·Annales de dermatologie et de vénéréologie·T KervarrecL Machet
Sep 1, 2011·Surgical Pathology Clinics·Justin A Bishop
Oct 8, 2011·Annales de dermatologie et de vénéréologie·M RafaaM-L Sigal
Feb 22, 2011·Journal of the American Medical Directors Association·Lilian N OguejioforVladimir Osipov
Dec 30, 2009·Actas dermo-sifiliográficas·R González-PérezR Soloeta
Apr 20, 2016·Clinical and Experimental Dermatology·T KanekoD Sawamura
Feb 11, 2014·Archives of Plastic Surgery·Syed M SayeedLaurence T Glickman
Jul 29, 2018·Skeletal Radiology·Ban Sharif, Asif Saifuddin
Sep 24, 2010·The Journal of Dermatology·Maiko KomatsuMasato Ueda
Feb 23, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Lina SaeedTheodora M Mauro
May 10, 2017·Virchows Archiv : an International Journal of Pathology·Yuichi YamadaYoshinao Oda
Aug 7, 2019·Proceedings·Meredith GavinMichelle Tarbox
Apr 21, 2020·International Journal of Dermatology·Leah A SwansonDavid J DiCaudo
Aug 28, 2020·International Journal of Dermatology·Francisca A AlvesOscar Tellechea

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.