PMID: 1103603Oct 6, 1975

Ischemic heart disease: an overview

The American Journal of Cardiology
R S Ross

Abstract

The studies on natural history of ischemic heart disease are reviewed and the major predictors of mortality identified. The severity of the coronary atherosclerosis and the status of ventricular function are found to be more important predictors of survival than the clinical presentation. The objectives of therapy in patients with ischemic heart disease are (1) to improve the quality of life by reducing symptoms, (2) to improve ventricular function, and (3) to increase survival time. The results of surgical therapy are examined in relation to these three objectives. Symptomatic improvement is present in 85 to 95 percent of patients after surgery, but convincing evidence for improved ventricular function is lacking and controlled studies of natural history have failed to show that surgery increases survival time. Analysis of the mechanism of symptomatic improvement after surgery suggests that increased blood flow to the ischemic area as well as infarction of ischemic myocardium and the nonspecific effects of surgery may account for the improvement. The prevention of coronary atherosclerosis is viewed as an attainable long-term solution to the problem of ischemic heart disease.

References

Jan 1, 1993·International Journal of Cardiac Imaging·F C VisserP J de Feyter
Jan 1, 1987·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·M M Khananashvili, N V Karsanov
Feb 1, 1981·Social Science & Medicine. Part E, Medical Psychology·P Sterling, J Eyer
Apr 8, 1998·Journal of the American College of Cardiology·R G Favaloro
Dec 25, 1975·The New England Journal of Medicine·S G Pauker
Oct 1, 1979·Annals of Surgery·F D LoopW L Proudfit
Nov 1, 1978·Clinical and Experimental Pharmacology & Physiology·G BaccelliA Zanchetti
Jun 1, 1977·British Heart Journal·M MnayerA E Raizner
Nov 1, 1978·British Heart Journal·R M DonaldsonR Balcon
Nov 1, 1978·British Heart Journal·P W SerruysJ M Detry
Dec 1, 1976·Postgraduate Medical Journal·E Braunwald
Nov 1, 1977·American Journal of Surgery·A E YoungN P Couch
Apr 1, 1984·American Heart Journal·A J RaperW J Paulsen
Apr 1, 1978·The American Journal of Cardiology·T A Preston, D A Spodick
Aug 1, 1979·American Heart Journal·G D Plotnick
Aug 1, 1978·The American Journal of Cardiology·B H GreenbergW W Parmley
Oct 1, 1979·The American Journal of Cardiology·H R BaurF L Gobel
Jan 25, 1979·The New England Journal of Medicine·F E KlosterP H Kanarek
Feb 1, 1981·Angiology·J B Chang
Apr 1, 1978·Circulation·D W MillerH T Dodge
Mar 1, 1978·Circulation·H D McIntosh, J A Garcia
Jan 1, 1979·Scandinavian Journal of Thoracic and Cardiovascular Surgery·A HallénS O Nyström
Feb 1, 1977·Circulation·C R Conti
Mar 1, 1977·Postgraduate Medicine·B L SegalW Likoff
Jan 1, 1980·Scandinavian Journal of Thoracic and Cardiovascular Surgery·P CarlensK Pehrsson
May 1, 1976·Postgraduate Medicine·R ZelisB H Roberts
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·A P SelwynA Jonathan
Jan 1, 1980·Upsala Journal of Medical Sciences·U EriksonG Ruhn
Jan 1, 1978·Acta Medica Scandinavica. Supplementum·R BalconG Fuerlicht

Citations

Feb 1, 1975·Annals of Internal Medicine·W S Aronow, E A Stemmer
May 1, 1975·Circulation·R S Ross
Jan 1, 1973·Circulation·D L BrewerA G Bartel
Jul 1, 1973·Circulation·M G BourassaJ Lespérance
Feb 1, 1974·The American Journal of Cardiology·C A BertolasiM R Vega
Jan 1, 1968·Scandinavian Journal of Thoracic and Cardiovascular Surgery·L BjörkG Ström
May 28, 1959·The New England Journal of Medicine·L A COBBR A Bruce
Apr 1, 1960·The American Journal of Cardiology·E G DIMONDJ E CROCKETT

Related Concepts

Coronary Artery Disease
Life Extension
Myocardium
Myocardial Stunning
Myocardial Infarction
Myocardial Ischemia
Blood Flow
Coronary Arteriosclerosis
Coronary Artery Bypass Surgery
Sinus Node Artery

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