Ischemic heart disease and ankylosing spondylitis-assessing the role of inflammation

Clinical Rheumatology
Michal Vinker ShusterHoward Amital

Abstract

To assess the association of ankylosing spondylitis (AS) and ischemic heart disease (IHD) compared to traditional cardiovascular (CV) risk factors. Primary care and hospital records of patients with AS were analyzed, using the largest health maintenance organization in Israel, the "Clalit" Health Services data. These patients were compared with age- and gender-matched controls regarding the proportion of IHD in a cross-sectional study. Parameters including socioeconomic status, body mass index (BMI), smoking habits, and coexistent medical conditions hypertension, hyperlipidemia, and diabetes mellitus (DM) - as well as the use of NSAIDs and anti-TNFs were also assessed. The study included 4076 AS patients compared to 20,290 age- and gender-matched controls without AS. The proportion of IHD was higher among AS patients as compared to controls (14.1 vs. 6.36%, respectively, p < 0.01) and patients treated with anti-TNFs had a lower risk for IHD compared to non-anti-TNF users. The proportion of hypertension, hyperlipidemia, DM, and smoking was also higher among AS patients. However, in multivariate analyses following adjustment to these risk factors, AS was not found to be associated with IHD nor anti-TNF therapy to be a protective ...Continue Reading

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Citations

Oct 2, 2020·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Gennadiy A KatsevmanSanjay Bhatia
May 1, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Qianqian GuYu Deng
Aug 28, 2020·Clinical Rheumatology·Anna SödergrenLennart T H Jacobsson
Jul 25, 2019·Current Vascular Pharmacology·Charalampos PapagorasAlexandros A Drosos

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