PMID: 1119401Apr 1, 1975

Ischemic heart failure: sustained inotropic response to small doses of I-epinephrine without toxicity

The American Journal of Cardiology
B HaiderT J Regan

Abstract

As a prelude to a study of severe ischemic heart failure, the therapeutic response of the ischemic ventricle to epinephrine and acetylstrophanthidin in nontoxic doses was determined in 24 intact anesthetized dogs undergoing a first episode of acute regional ischemia. A thrombotic obstruction was produced in the left ventricular dysfunction. The elevation of end-diastolic pressure and reduced stroke volume in control dogs were not significantly altered by administration of strophanthidin. Epinephrine (0.05 mug/kg per min) elicited a significant reduction in end-diastolic pressure and increase in stroke volume. The latter was not attended by an increased incidence of ventricular fibrillation, whereas fibrillation occurred in half of the group given strophantihidin. Thus, the catecholamine was selected to study pump failure. Severe ischemic heart failure was assessed in two groups with scar from previous infarction for up to 4 hours. By 60 minutes of ischemia the increase in end-diastolic pressure and volume and decrease in stroke volume and ejection fraction were comparable in both groups. Thereafter, alternate animals received small doses of epinephrine (0.05 to 0.15 mug/kg per min) with graded increments at 60 minute intervals ...Continue Reading

References

Feb 1, 1986·The Journal of Clinical Investigation·S BakthT J Regan
Aug 1, 1980·Anaesthesia and Intensive Care·W B Runciman

Citations

Jul 1, 1968·The Journal of Clinical Investigation·M J Frank, G E Levinson
Jan 1, 1969·Pflügers Archiv : European journal of physiology·E Carmeliet, J Vereecke
Sep 14, 1972·The New England Journal of Medicine·S H RahimtoolaR M Gunnar
Aug 1, 1972·The Journal of Physiology·M Morad, E L Rolett
Nov 1, 1972·Circulation·J VidebaekB Sterndorff
Mar 1, 1971·The Journal of Clinical Investigation·P Hamosh, J N Cohn
Jul 1, 1970·Cardiovascular Research·T J ReganW M Burke
Mar 1, 1969·American Heart Journal·J J MorrisH D McIntosh
Nov 1, 1965·The American Journal of Cardiology·W G Austen, J M Moran
Apr 1, 1960·The American Journal of Cardiology·M MALACH, B A ROSENBERG

Related Concepts

Ischemia
Ventricular Fibrillation
K-Strophanthidin
Catecholamine [EPC]
Diastolic Blood Pressure
Tachyphylaxis
Fibrillation
Ventricular Dysfunction, Left
Myocardial Infarction
Myocardial Ischemia

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