PMID: 9434702Jan 22, 1998Paper

Ischemic intervals during warm blood cardioplegia in the canine heart evaluated by phosphorus 31-magnetic resonance spectroscopy

The Journal of Thoracic and Cardiovascular Surgery
N C de OliveiraG A Geffin

Abstract

Warm blood cardioplegia requires interruption by ischemic intervals to aid visualization. We evaluated the safety of repeated interruption of warm blood cardioplegia by normothermic ischemic periods of varying durations. In three groups of isolated cross-perfused canine hearts, left ventricular function was measured before and for 2 hours of recovery after arrest, which comprised four 15-minute periods of cardioplegia alternating with three ischemic intervals of 15, 20, or 30 minutes (I15, I20, and I30). Metabolism was continuously measured by phosphorus 31-magnetic resonance spectroscopy. Adenosine triphosphate level fell progressively as ischemia was prolonged; after recovery, adenosine triphosphate was 99% +/- 6%, 90% +/- 1% (p = 0.0004 vs control), and 68% +/- 3% (p = 0.0002) of control levels in I15, I20, and I30, respectively. Intracellular acidosis with ischemia was most marked in I30. After recovery, left ventricular maximal systolic elastance at constant heart rate and coronary perfusion pressure was maintained in I15 but fell to 85% +/- 3% in I20, (p = 0.003) and to 65% +/- 6% (p = 0.003) of control values in I30, while relaxation (tau) was prolonged only in I30 (p = 0.007). Hearts recover fully after three 15-minutes...Continue Reading

References

Nov 1, 1995·Circulation·S V LichtensteinS E Fremes
Mar 1, 1995·The Annals of Thoracic Surgery·N HayashidaD A Mickle
Nov 1, 1993·The Annals of Thoracic Surgery·T M YauL C Tumiati
Nov 1, 1995·The Annals of Thoracic Surgery·E F HoffenbergR Deslauriers

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Citations

Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M S AvidanR A Sherwood
Jul 1, 2020·Texas Heart Institute Journal·Taylor M JamesSotiris C Stamou
Sep 15, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A B EricssonJ Vaage
Aug 2, 2000·The Annals of Thoracic Surgery·D F TorchianaG A Geffin

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