Ischemic preconditioning and postconditioning alleviates hippocampal tissue damage through abrogation of apoptosis modulated by oxidative stress and inflammation during transient global cerebral ischemia-reperfusion in rats

Chemico-biological Interactions
Muhammed A SaadA S Attia

Abstract

It has been argued recently that ischemic preconditioning (IPre) and postconditioning (IPost) have beneficial effects in many ischemic disorders however; their effects on global ischemia/reperfusion (I/R) are poorly understood. Thus, the present work aimed to study the possible mechanisms underlying the neuroprotective effects of IPre and IPost. Animals were randomly allocated into 4 groups (n = 30): (1) Sham operated (SO); (2) I/R group, animals were subjected to 15 min global ischemia followed by 60 min reperfusion; (3) IPre, animals were subjected to 3 episodes of 5 min ischemia followed by 10 min reperfusion before I/R; (4) IPost, animals were subjected to three episodes of 10s of ischemia and 10s of reperfusion after the period of ischemia followed by a 60 min reperfusion period. Lactate dehydrogenase activity, oxidative stress, inflammatory and apoptotic biomarkers, as well as neurotransmitters, infarct size and histopathological examination were assessed. I/R induced hippocampal damage through increasing oxidative stress, inflammatory, excitotoxic and apoptotic markers as well as lactate dehydrogenase activity and infarct size. Both, IPre and IPost attenuated most markers induced by I/R. IPre and IPost neuroprotective ef...Continue Reading

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Citations

Sep 8, 2015·Experimental Gerontology·Jamila R SanchezRochelle Buffenstein
Aug 27, 2016·Biochemical and Biophysical Research Communications·Zhiqiang ChenZhongye Sun
Jan 23, 2017·Progress in Neurobiology·Sijie LiXunming Ji
Jan 21, 2017·International Journal of Molecular Sciences·Stefanie EndesfelderThomas Schmitz
Mar 2, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Jie LinZhong Zeng
Aug 31, 2016·Molecular Medicine Reports·Zhiyou CaiGuanghui Chen
Jan 29, 2019·Frontiers in Physiology·Wen-Ting LiaoWen-Yuan Liu

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