Ischemic preconditioning as a possible explanation for the age decline relative mortality in sleep apnea

Medical Hypotheses
L Lavie, P Lavie

Abstract

Breathing disorders in sleep are prevalent phenomena profoundly affecting the cardiovascular system. Mortality studies of sleep apnea patients revealed maximum risk of dying in younger patients and a pronounced age-decline in relative mortality reaching non significant levels in patients older than 50 years. We hypothesize that the age decline mortality risk in sleep apnea can be explained by cardiovascular and cerebrovascular protection conferred by ischemic preconditioning resulting from the nocturnal cycles of hypoxia-reoxygenation. The association of ischemic preconditioning with increase levels of vascular endothelial growth factor, increased production of oxygen reactive species, heat shock proteins, adenosine, and TNF-alpha, all demonstrated in sleep apnea, provide preliminary support to our hypothesis.

References

Jan 1, 1991·Thorax·J M GoldmanJ C Biggs
Apr 29, 1993·The New England Journal of Medicine·T YoungS Badr
Apr 29, 1993·The New England Journal of Medicine·E A Phillipson
Apr 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C PeraltaJ Roselló-Catafau
Aug 23, 2001·Trends in Molecular Medicine·G L Semenza
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·Richard SchulzFriedrich Grimminger
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Larissa DyugovskayaLena Lavie
Jul 11, 2002·American Journal of Physiology. Cell Physiology·Alexander E KabakovHarm H Kampinga
Jul 13, 2002·Respiratory Medicine·D FisherP Lavie
Jul 29, 2003·The European Respiratory Journal·N MeslierJ L Racineux
Apr 15, 2004·Journal of Molecular and Cellular Cardiology·Shoji FukudaNilanjana Maulik
Aug 11, 2004·Mayo Clinic Proceedings·James M Parish, Virend K Somers
Feb 11, 2005·Molecular Pharmacology·Joel Linden
Mar 2, 2005·The European Respiratory Journal·P LavieP Herer
May 27, 2005·The Journal of Surgical Research·Yih-Sharng ChenChau-Fong Chen

❮ Previous
Next ❯

Citations

Nov 16, 2011·Pflügers Archiv : European journal of physiology·Richard S T LeungDaniel Stevens
Jan 24, 2013·Sleep & Breathing = Schlaf & Atmung·Wojciech KukwaAnna M Czarnecka
Jul 4, 2012·Current Neurology and Neuroscience Reports·Molly E Zimmerman, Mark S Aloia
May 26, 2009·American Journal of Epidemiology·Yohannes W EndeshawDonald L Bliwise
Feb 7, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yohannes W EndeshawDonald L Bliwise
Dec 14, 2011·American Journal of Respiratory and Critical Care Medicine·Lena Lavie, Peretz Lavie
Sep 18, 2012·American Journal of Respiratory and Critical Care Medicine·Miguel-Angel Martínez-GarcíaJosep-Maria Montserrat
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Slava BergerLena Lavie
Nov 17, 2012·American Journal of Respiratory and Critical Care Medicine·Francisco Campos-RodriguezUNKNOWN Spanish Sleep Network
Dec 19, 2013·PloS One·Ivana RosenzweigMary J Morrell
Jan 24, 2014·Cardiology Research and Practice·Elizabeth StopfordVikrant Nayar
Jun 8, 2014·Sleep Medicine·Miguel A Martínez-GarcíaUNKNOWN Spanish Sleep Network
Mar 29, 2014·American Journal of Respiratory and Critical Care Medicine·Francisco Campos-RodriguezCarmen V Almeida-Gonzalez
Sep 5, 2014·Current Opinion in Pulmonary Medicine·Ivana RosenzweigMary J Morrell
Oct 24, 2008·Archives of Physiology and Biochemistry·Lena LavieAndrey Polyakov
Jun 29, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Slava Berger, Lena Lavie
Jun 29, 2010·Archivos de bronconeumología·Miguel Angel Martínez-GarcíaJosé María Montserrat
Oct 5, 2007·Progress in Neurobiology·Weihong Pan, Abba J Kastin
Feb 6, 2007·Sleep Medicine Reviews·Sandrine H LaunoisPatrick Lévy
Dec 26, 2006·Journal of Molecular and Cellular Cardiology·Pauline C BéguinChristophe Ribuot
Jul 17, 2009·Anaesthesia·W A EnglishJ P Nolan
Apr 13, 2011·Fundamental & Clinical Pharmacology·Elise BelaidiDiane Godin-Ribuot
Aug 12, 2009·Journal of Sleep Research·Peretz Lavie, Lena Lavie
Nov 24, 2007·Clinics in Geriatric Medicine·Daniel Norman, José S Loredo
May 21, 2016·Sleep Medicine·Daniel López-PadillaMaría Josefa Díaz de Atauri
May 22, 2013·Pulmonary Medicine·Fernando De Torres-AlbaJosé Luis López-Sendon
Sep 3, 2013·Respiratory Physiology & Neurobiology·Juliana C PerrySergio Tufik
Dec 21, 2010·Autonomic Neuroscience : Basic & Clinical·Juliana C PerrySergio Tufik
Jan 1, 2015·Nature Reviews. Disease Primers·Patrick LévyJean-Louis Pépin
Jun 27, 2015·The Canadian Journal of Cardiology·Michael ArztStefan Buchner
Apr 19, 2015·The Lancet. Respiratory Medicine·Ivana RosenzweigMary J Morrell
Jan 11, 2013·International Journal of Cardiology·Francisco Garcia-RioTeresa Ramírez
Jun 21, 2016·Neurophysiologie clinique = Clinical neurophysiology·Agnès DauratMichel Tiberge
Mar 1, 2016·Chest·Juan F MasaUNKNOWN Spanish Sleep Network(∗)
Mar 10, 2015·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Guilherme Silva JulianJair Ribeiro Chagas
May 5, 2017·Journal of the American Geriatrics Society·Andrew M NamenEdward F Haponik
Jan 7, 2017·American Journal of Respiratory and Critical Care Medicine·Andrée-Ann BarilNadia Gosselin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.