PMID: 8945925Nov 1, 1996Paper

Ischemic preconditioning attenuates postischemic leukocyte adhesion and emigration

The American Journal of Physiology
T AkimitsuRonald J Korthuis

Abstract

Intravital microscopy was used to determine whether ischemic preconditioning (IPC; 5 min ischemia and 10 min reperfusion) would attenuate leukocyte adhesion and emigration induced by subsequent prolonged ischemia (60 min) and reperfusion (60 min) (I/R) in murine cremaster muscle and whether adenosine produced during IPC and/or reperfusion contributed to these beneficial effects. I/R elicited a marked increase in the number of adherent and emigrated leukocytes compared with the nonischemic control muscles, an effect that was largely prevented by IPC. Superfusion of the cremaster with adenosine deaminase only during IPC or only during 60-min reperfusion attenuated the inhibitory effect of IPC on postischemic leukocyte adhesion and emigration. However, the beneficial effects of IPC were mimicked in cremaster muscles preconditioned with adenosine (topical application for 10 min beginning 20 min before the onset of prolonged ischemia). Similar results were obtained in experiments in which adenosine was topically applied to the cremaster only during the 60-min reperfusion period. Our findings suggest that the ability of IPC to attenuate postischemic leukocyte adhesion and emigration may be mediated by adenosine released during IPC an...Continue Reading

Citations

Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·P BauerD N Granger
Dec 21, 2000·American Journal of Physiology. Heart and Circulatory Physiology·S ShigematsuR J Korthuis
Aug 12, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R A HopperC Y Pang
Aug 16, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Taiji YamaguchiRonald J Korthuis
Sep 8, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fabienne TamionChristian Thuillez
Aug 24, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A TsujikawaY Ogura

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