PMID: 8945892Nov 11, 1996Paper

Ischemic preconditioning in human and rat ventricle

The American Journal of Physiology
J C ClevelandA Banerjee

Abstract

The signal transduction of ischemic preconditioning involves activation of endogenous receptor-based systems, including alpha 1-adrenoceptors and adenosine receptors. Whereas preconditioning protects against ischemia-reperfusion injury, it is unknown whether this protective strategy might be useful clinically. Furthermore, human atrium has been successfully preconditioned, but it is unknown whether human ventricle can be functionally protected against hypoxia-reoxygenation. To study these questions, isolated rat ventricle and human ventricular trabeculae were suspended in an organ bath and subjected to 30 min of hypoxia and 60 min of reoxygenation. In the rat ventricle, preconditioning was induced by 5 min of rapid pacing at 3 Hz in hypoxic buffer without glucose (simulated ischemia), alpha 1-adrenoceptor stimulation (phenylephrine), or adenosine receptor stimulation (adenosine). In the human trabeculae the effects of preceding simulated ischemia and alpha 1-adrenoceptor and adenosine receptor stimulation were examined against hypoxia-reoxygenation. In the rat, pretreatment with simulated ischemia and alpha 1-adrenoceptor and adenosine receptor stimulation improved recovery of developed tension (56 +/- 3, 56 +/- 4, and 58 +/- 2...Continue Reading

Citations

Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A K GamperlA P Farrell
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jin HanEuiyong Kim
Dec 26, 2001·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·K HeardC B Cairns
Mar 10, 2001·The Annals of Thoracic Surgery·R P Scott

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