PMID: 9556000Apr 29, 1998Paper

Ischemic preconditioning of musculocutaneous flaps: effects of ischemia cycle length and number of cycles

Annals of Plastic Surgery
T M ZahirJ G Thomson

Abstract

Previous work in our laboratory has indicated that ischemic preconditioning improves musculocutaneous flap survival 2.5 times that of the control flap area when the flaps are subsequently subjected to 4 hours of global ischemia. The preconditioning protocol used in this study was arbitrarily designed to be 10 minutes of pedicle clamping followed by 10 minutes of reperfusion. This sequence was repeated for three cycles with a total preconditioning time of 1 hour. There are no published works comparing different preconditioning protocols in musculocutaneous flaps. The goal of this study was to determine if the ischemic cycle time and the number of cycles influenced the effectiveness of ischemic preconditioning. Fifty-one male Sprague-Dawley rats were divided into one control and six treatment groups of 6 to 10 animals in each group. A transverse rectus abdominis musculocutaneous flap based on the inferior epigastric vessels was elevated in each animal. Flaps were preconditioned by pedicle clamping and reperfusion for either 5 or 10 minutes per cycle. This was repeated for one, two, or three cycles. Controls were simply perfused for 30 minutes. Each flap was then subjected to 4 hours of global ischemia. Flap surface survival area ...Continue Reading

Citations

Sep 27, 2005·Microsurgery·Claudiu F MarianMihai Ionac
Apr 1, 2000·The Journal of Trauma·M H ChengE Brey
Dec 23, 2008·The Journal of Surgical Research·Soner TatlidedeWilliam G Austen
Jun 24, 2008·The Journal of Surgical Research·Kyle R EberlinWilliam G Austen
Dec 21, 2000·British Journal of Plastic Surgery·H MatsumuraK Watanabe
Dec 3, 2014·The Journal of Surgical Research·Emre A KocmanCengiz Cetin
Jan 16, 2009·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Wolfgang EichhornMax Heiland
Sep 26, 2006·Annals of Plastic Surgery·O Koray CoskunfiratMustafa B Dikici
Nov 13, 2007·Microsurgery·Honggang WangXiaolin Liu
Mar 10, 2006·Plastic and Reconstructive Surgery·Alizan A KhalilJohn C Hall
Oct 30, 2009·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·Birol CivelekSelim Celebioglu
May 10, 2017·Clinical Hemorheology and Microcirculation·J KolbenschlagM Lehnhardt

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