Ischemic stroke across sexes: What is the status quo?

Frontiers in Neuroendocrinology
Luca LiberaleGiovanni G Camici

Abstract

Stroke prevalence is expected to increase in the next decades due to the aging of the Western population. Ischemic stroke (IS) shows an age- and sex-dependent distribution in which men represent the most affected population within 65 years of age, being passed by post-menopausal women in older age groups. Furthermore, a sexual dimorphism concerning risk factors, presentation and treatment of IS has been widely recognized. In order to address these phenomena, a number of issue have been raised involving both socio-economical and biological factors. The latter can be either dependent on sex hormones or due to intrinsic factors. Although women have poorer outcomes and are more likely to die after a cerebrovascular event, they are still underrepresented in clinical trials and this is mirrored by the lack of sex-tailored therapies. A greater effort is needed in the future to ensure improved treatment and quality of life to both sexes.

Citations

Oct 12, 2018·Cellular and Molecular Neurobiology·Rachida GuennounMichael Schumacher
Jan 29, 2020·Cardiovascular Research·Sarah Costantino, Francesco Paneni
Sep 24, 2019·Molecular Medicine Reports·Zhongsheng ZhangSichun Huang
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fatemeh MahboobifardMohammad H Pourgholami
Jun 3, 2021·European Journal of Clinical Investigation·Luca LiberaleGiovanni G Camici
Apr 27, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yuedong TangMing Liu

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