Ischemic stroke in a 7-month-old infant with antiphospholipid antibody and homozygous C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism

Journal of Child Neurology
Se Hee KimByung Chan Lim

Abstract

Prothrombotic risk factors in children with ischemic stroke have been increasingly recognized with recent developments in technology. Extensive evaluation including a detailed family history is required to identify various inherited or acquired prothrombotic conditions. We report a 7-month-old male who presented with right hemiparesis. Acute cerebral infarction in the area supplied by the left lenticulostriate artery was confirmed through magnetic resonance imaging. De novo synthesis of antiphospholipid antibodies and homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism were identified as presumed prothrombotic risk factors. His twin sister and mother were also positive for antiphospholipid antibodies. Multiple risk factors for ischemic stroke should be considered, particularly in the perinatal and infancy period. This case also underlines the rare familial occurrence of antiphospholipid antibodies and its relationship to ischemic stroke in infancy.

References

Nov 1, 1995·The American Journal of Medicine·S N GoldbergT P Greco
Mar 23, 2005·Archives of Disease in Childhood·S HaywoodV Ganesan
Jun 10, 2006·Lupus·A M Soares RolimM B Santiago
Dec 2, 2006·Arthritis and Rheumatism·Y BerkunG Kenet
Apr 3, 2008·Pediatric Clinics of North America·Timothy J Bernard, Neil A Goldenberg

❮ Previous
Next ❯

Citations

Nov 30, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Carla ArpinoPaolo Curatolo
Aug 17, 2011·European Journal of Pediatrics·Marta CabralHelena Carreiro
Apr 17, 2012·Journal of Clinical Ultrasound : JCU·Ivan IvanovMargarita Panova
Jul 17, 2015·Journal of Korean Neurosurgical Society·Young Seok Park
Jan 29, 2011·Pediatric Hematology and Oncology·Fuat Emre Canpolat, Ferhat Cekmez
Jun 11, 2020·World Journal of Clinical Cases·Beata Sarecka-Hujar, Ilona Kopyta

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.