Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.

Thrombosis Journal
John W ColeSteven J Kittner

Abstract

Although cigarette smoking is a well-established risk factor for vascular disease, the genetic mechanisms that link cigarette smoking to an increased incidence of stroke are not well understood. Genetic variations within the genes of the inflammatory pathways are thought to partially mediate this risk. Here we evaluate the association of several inflammatory gene single nucleotide polymorphisms (SNPs) with ischemic stroke risk among young women, further stratified by current cigarette smoking status. A population-based case-control study of stroke among women aged 15-49 identified 224 cases of first ischemic stroke (47.3% African-American) and 211 age-comparable control subjects (43.1% African-American). Several inflammatory candidate gene SNPs chosen through literature review were genotyped in the study population and assessed for association with stroke and interaction with smoking status. Of the 8 SNPs (across 6 genes) analyzed, only IL6 SNP rs2069832 (allele C, African-American frequency = 92%, Caucasian frequency = 55%) was found to be significantly associated with stroke using an additive model, and this was only among African-Americans (age-adjusted: OR = 2.2, 95% CI = 1.0-5.0, p = 0.049; risk factor adjusted: OR = 2.5, ...Continue Reading

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Citations

Apr 14, 2009·Current Atherosclerosis Reports·Myriam Fornage
Jan 15, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Qianqian YaoChang Zhou
Jun 13, 2015·Molekuliarnaia biologiia·B V TitovO O Favorova
Aug 15, 2009·Stroke; a Journal of Cerebral Circulation·Armin J GrauFlorian Buggle
Nov 24, 2020·Journal of Molecular Neuroscience : MN·Xi-Xi GuYe-Sheng Wei
Jun 17, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Said El ShamiehSophie Visvikis-Siest

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Methods Mentioned

BETA
dissection
genotyping
PCR

Software Mentioned

SAS

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