Mar 1, 1975

Iskedyl and general anesthesia. Measurement of the systolic ejection volume and peripheral resistance using the arterial pressure curves

Annales de l'anesthésiologie française
G LaboritR Neff


ISKEDYL (PF 50), which is sold as a vasoregulator of cerebral irrigation, consists of a mixture of dihydroergocristine and raubasine. This work aims at determining possible interactions between this product and certain drugs used in anesthesia from the cardiovascular point of view. ISKEDYL does not seem to be a contraindication to anesthesia of the "neuroleptic" type, when injected in pre-, per- or post-operative period. A slight temporary and spontaneously reversible fall in arterial blood pressure, affecting both maximum and minimum pressure, together with a decrease in stroke volume and peripheral resistances, estimated by the study of the arterial blood pressure curve, seem to indicate that this product has peripheral vaso-dilatory properties.

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Mentioned in this Paper

Arterial Pulse Pressure
Yohimbin Spiegel
Total Peripheral Resistance
Vasomotor System
Diastolic Blood Pressure
Pulmonary Vascular Resistance
Antipsychotic Agents
General Anesthesia [PE]

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