Islet-1 immunoreactivity in the developing retina of Xenopus laevis

TheScientificWorldJournal
Guadalupe Álvarez-HernánJavier Francisco-Morcillo

Abstract

The LIM-homeodomain transcription factor Islet1 (Isl1) has been widely used as a marker of neuronal differentiation in the developing visual system of different classes of vertebrates, including mammals, birds, reptiles, and fish. In the present study, we analyzed the spatial and temporal distribution of Isl1-immunoreactive cells during Xenopus laevis retinal development and its relation to the formation of the retinal layers, and in combination with different markers of cell differentiation. The earliest Isl1 expression appeared at St29-30 in the cell nuclei of sparse differentiating neuroblasts located in the vitreal surface of the undifferentiated retina. At St35-36, abundant Isl1-positive cells accumulated at the vitreal surface of the neuroepithelium. As development proceeded and through the postmetamorphic juveniles, Isl1 expression was identified in subpopulations of ganglion cells and in subsets of amacrine, bipolar, and horizontal cells. These data together suggest a possible role for Isl1 in the early differentiation and maintenance of different retinal cell types, and Isl1 can serve as a specific molecular marker for the study of retinal cell specification in X. laevis.

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Citations

Jul 1, 2015·Experimental Eye Research·Ruth Bejarano-EscobarJavier Francisco-Morcillo
Aug 4, 2016·Frontiers in Neuroanatomy·Henrik BoijeFinn Hallböök
Jul 31, 2019·PloS One·Jee Yoon ShinBong-Gun Ju
Mar 28, 2018·Journal of Anatomy·Guadalupe Álvarez-HernánJavier Francisco-Morcillo
Feb 16, 2021·Frontiers in Cell and Developmental Biology·José Antonio de Mera-RodríguezJavier Francisco-Morcillo

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