PMID: 18411183Nov 1, 1991Paper

Islet amyloid polypeptide: the cause of type-2 diabetes?

Trends in Endocrinology and Metabolism : TEM
D Bretherton-Watt, S R Bloom

Abstract

Islet amyloid polypeptide (IAPP or amylin), first identified as the peptide deposited as amyloid in type-2 diabetic pancreas and insulinoma, turns out to be a peptide produced in the pancreatic beta-cell secretory granule that is costored and coreleased with insulin. Experimental evidence suggests that, under certain conditions, IAPP can counter insulin action in peripheral tissue and inhibit insulin release from the pancreas. IAPP therefore appears to respond to the same physiologic stimuli as insulin, but has opposing biologic actions. The role of IAPP, both in normal physiology and in pathology, remains unclear, but current evidence suggests against a role as a circulating hormone in favor of a paracrine or autocrine modulator of insulin secretion.

References

Mar 30, 1990·Biochemical and Biophysical Research Communications·H C FehmannR Arnold
Mar 1, 1990·The Journal of Clinical Investigation·A OgawaK L Luskey
Feb 1, 1990·The Journal of Endocrinology·M A GhateiS R Bloom
Mar 16, 1990·Biochemical and Biophysical Research Communications·K H JohnsonP Westermark
Jun 15, 1990·Biochemical and Biophysical Research Communications·K JordanK H Johnson
Aug 16, 1990·Biochemical and Biophysical Research Communications·T D O'BrienK H Johnson
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Oct 1, 1988·Regulatory Peptides·M Pettersson, B Ahrén
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G J CooperK B Reid

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Citations

Jan 1, 1993·Acta Oncologica·C BetsholtzP Westermark
Jun 1, 1994·Psychonomic Bulletin & Review·M Kubovy
Jul 12, 2019·Frontiers in Aging Neuroscience·George A Edwards IiiInes Moreno-Gonzalez

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