PMID: 11921412Mar 29, 2002Paper

Islet autoantibodies in cord blood: maternal, fetal, or neither?

Diabetes/metabolism Research and Reviews
Marian Rewers

Abstract

In high-risk type 1 diabetes populations, up to 3% of the general population newborns may express islet autoantibodies in cord blood and the vast majority of those appear to be maternal autoantibodies that disappear usually before the age of 9 months. Despite recent progress in standardization of autoantibody assays, some of the findings appear to be artifacts or non-IgG-mediated binding phenomena. It remains unclear whether transplacentally transmitted maternal autoantibodies play any role in protecting the offspring of diabetic women from diabetes. The evidence for fetal production of islet autoantibodies is very limited and remains to be validated in large prospective studies currently underway.

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Citations

May 10, 2013·Diabetologia·L C Stene, E A M Gale
Jan 5, 2007·Reviews in Endocrine & Metabolic Disorders·Hui Peng, William Hagopian
Feb 15, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·K F LynchUNKNOWN Diabetes Prediction in Skåne (DiPiS) Study Group
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Karin LarssonAke Lernmark

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