Islet autoimmunity status in Asians with young-onset diabetes (12-40 years): association with clinical characteristics, beta cell function and cardio-metabolic risk factors

Diabetes Research and Clinical Practice
A C ThaiASDIAB Study Group

Abstract

In this paper, the islet autoimmunity status and relation to clinical characteristics, beta cell function and cardio-metabolic risk factors in young-onset Asian diabetic patients are evaluated at baseline. The study population consisted of 912 patients (from China, India, Malaysia and Singapore) with age 12-40 years and diabetes duration <12 months. Autoantibodies to glutamic acid decarboxylase (GADA) and tyrosine phosphatase (IA-2A), beta cell function and cardio-metabolic risk parameters were assessed. Among our young patient cohort, 105 (11.5%) patients were GADA and/or IA-2A positives (Ab +ve). Ab +ve patients were younger, leaner, had more severe hyperglycaemia and lower beta cell function. The frequency of metabolic syndrome was significantly lower in Ab +ve patients (27%) compared to Ab -ve patients (54%). However, a substantial proportion of patients in both groups of patients had atherogenic dyslipidaemia, hypertension and albuminuria (micro or macro). In our study cohort, only one in 10 Asian youth with new-onset diabetes had evidence of islet autoimmunity. At least 60% of Ab +ve and 50% of Ab -ve patients demonstrated classical features of type 1 and type 2 diabetes respectively. Regardless of autoimmunity status, th...Continue Reading

References

Nov 1, 1990·Diabetes Research and Clinical Practice·T OtaniY Hirata
Aug 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·H J ArnqvistL Wibell
Mar 21, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·V MohanI R MacKay
Apr 13, 1999·Diabetes Research and Clinical Practice·W M Wan NazaimoonB A Khalid
May 23, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·J K LiC S Cockram
Oct 12, 2000·Diabetes Research and Clinical Practice·C S Cockram
Feb 15, 2003·Journal of Pediatric Endocrinology & Metabolism : JPEM·S LikitmaskulC Tuchinda
Mar 29, 2003·Diabetes Care·Ambady RamachandranViswanathan Vijay
Aug 20, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·C Y PanUNKNOWN ASDIAB Study Group
Dec 24, 2005·Diabetes Care·UNKNOWN American Diabetes Association
Jan 31, 2006·Diabetes Care·Dana DabeleaUNKNOWN SEARCH for Diabetes in Youth Study Group
May 20, 2006·Current Medical Research and Opinion·Maike C EppensUNKNOWN International Diabetes Federation Western Pacific Region Steering Committee
Aug 19, 2006·BMJ : British Medical Journal·Yangfeng Wu
Nov 14, 2006·Lancet·Kun-Ho YoonHo-Young Son
Nov 30, 2006·Annals of the New York Academy of Sciences·Yongsoo Park

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Citations

Aug 2, 2013·Diabetes Technology & Therapeutics·Kuppan GokulakrishnanViswanathan Mohan
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Jul 14, 2010·Pediatric Diabetes·Louis C K Low
Oct 22, 2011·The Korean journal of laboratory medicine·Hyewon ParkEun Young Song

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